Epidemiology of blood culture-proven bacterial sepsis in children in Switzerland: a population-based cohort study

The Lancet Child & Adolescent Health
Philipp K A AgyemanSwiss Pediatric Sepsis Study

Abstract

Sepsis is a leading cause of childhood mortality worldwide. We assessed population-based incidence and outcomes of blood culture-proven bacterial sepsis in children in Switzerland. We did a multicentre, prospective, cohort study at ten paediatric hospitals in Switzerland. We included neonates and children younger than 17 years with blood culture-proven bacterial sepsis. Children were eligible if they met criteria for systemic inflammatory response syndrome-according to 2005 paediatric consensus definition- at the time of blood culture sampling. Incidence was calculated by dividing the number of annual sepsis episodes in the study for the years 2012-15 by the end-of-year resident paediatric population in Switzerland. The primary outcome was in-hospital mortality in the first 30 days after sepsis onset. Between Sept 1, 2011, and Dec 31, 2015, we enrolled 1096 children to our study. Of 1181 episodes of blood culture-proven bacterial sepsis, 382 (32%) occurred in 379 previously healthy children, 402 (34%) in 391 neonates, and 397 (34%) in 341 children with comorbidities. Incidence was 25·1 cases per 100 000 (95% CI 23·8-26·4) in children and 146·0 cases per 100 000 (133·2-159·6) in neonates. Central line-associated bloodstream infe...Continue Reading

References

Jan 8, 2005·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Brahm GoldsteinUNKNOWN International Consensus Conference on Pediatric Sepsis
Oct 17, 2009·Journal of Medical Microbiology·Katherine L HendersonMike Sharland
Mar 11, 2010·The Pediatric Infectious Disease Journal·Shamez LadhaniMike Sharland
Aug 10, 2010·Nature Genetics·Sonia DavilaUNKNOWN International Meningococcal Genetics Consortium
Oct 30, 2012·The Lancet Infectious Diseases·Mitchell M LevyR Phillip Dellinger
Jan 31, 2013·Intensive Care Medicine·R P DellingerUNKNOWN Surviving Sepsis Campaign Guidelines Committee including The Pediatric Subgroup
Feb 13, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·K B Laupland
Mar 12, 2013·Lancet·Jean-Louis VincentKevin J Tracey
Mar 12, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M Goto, M N Al-Hasan
Mar 30, 2013·The Pediatric Infectious Disease Journal·Marjo LanttoMatti Uhari
Jul 31, 2013·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Mary E HartmanR Scott Watson
Sep 17, 2014·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Amanda RuthKiran B Hebbar
Dec 4, 2014·The Lancet Infectious Diseases·Walter ZinggUNKNOWN systematic review and evidence-based guidance on organization of hospital infection control programmes (SIGHT) study group
Mar 4, 2015·American Journal of Respiratory and Critical Care Medicine·Scott L WeissUNKNOWN Sepsis Prevalence, Outcomes, and Therapies (SPROUT) Study Investigators and Pediatric Acute Lung Injury and Sepsis Investiga
Mar 5, 2015·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Mirjana CvetkovicMark J Peters
Nov 5, 2015·The Pediatric Infectious Disease Journal·Eric GiannoniUNKNOWN Swiss Pediatric Sepsis Study Group
Feb 24, 2016·JAMA : the Journal of the American Medical Association·Mervyn SingerDerek C Angus
Jan 7, 2017·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·John C LinUNKNOWN Sepsis Prevalence, Outcomes, and Therapy Study Investigators
Feb 22, 2017·Intensive Care Medicine·Luregn J SchlapbachUNKNOWN Australian & New Zealand Intensive Care Society (ANZICS) Centre for Outcomes & Resource Evaluation (CORE) and Australian & N

❮ Previous
Next ❯

Citations

Feb 8, 2020·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Scott L WeissPierre Tissieres
Jul 25, 2019·Current Opinion in Infectious Diseases·Luregn J Schlapbach
Mar 30, 2020·The Pediatric Infectious Disease Journal·Laila S Al YazidiAlison Kesson
Apr 1, 2020·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Fleur LortonElise Launay
Mar 14, 2020·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Luregn J SchlapbachGraeme MacLaren
May 8, 2018·Experimental and Therapeutic Medicine·Qinhao Li, Xiaona Gong
Aug 24, 2018·Frontiers in Pediatrics·Alexa DierigUNKNOWN Swiss Pediatric Sepsis Study
Jan 1, 2020·Critical Care : the Official Journal of the Critical Care Forum·Luregn J SchlapbachUNKNOWN Australian & New Zealand Intensive Care Society (ANZICS) Centre for Outcomes & Resource Evaluation (CORE) and the Australian
Oct 30, 2019·Open Forum Infectious Diseases·F SeckaS T Anderson
Mar 21, 2020·Pediatric Research·Eleanor J MolloyUNKNOWN on behalf of the Infection, Inflammation, Immunology and Immunisation (I4) section of the ESPR
Mar 19, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Alessandro BorghesiLuregn J Schlapbach
Jan 3, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sandra A AsnerChristoph Berger
Jul 28, 2018·Frontiers in Immunology·Anina SchneiderEric Giannoni
May 28, 2019·Frontiers in Pediatrics·Amanda HarleyLuregn J Schlapbach
Jan 14, 2020·International Journal of Pediatrics·Varsha Vekaria-HiraniIdris N Chipkophe
Sep 19, 2018·European Journal of Pediatrics·Federica ZalloccoSalvatore Cazzato
Nov 5, 2020·Immunological Reviews·Maria PapadopoulouDavid Vermijlen
Aug 11, 2020·The Pediatric Infectious Disease Journal·Joachim LuthanderAnna Nilsson
Dec 18, 2020·Frontiers in Pediatrics·Eric Giannoni, Luregn J Schlapbach
Nov 5, 2020·Journal of the American College of Emergency Physicians Open·Andrea T CruzLuregn J Schlapbach
Mar 30, 2021·Frontiers in Medicine·Ritu Banerjee, Romney Humphries
Dec 11, 2020·The Pediatric Infectious Disease Journal·Christian Magnus ThaulowStig Harthug
Jul 17, 2021·Journal of Pediatric Gastroenterology and Nutrition·Thomas Jack
Oct 7, 2021·Critical Care Medicine·Kusum MenonUNKNOWN Pediatric Sepsis Definition Taskforce of the Society of Critical Care Medicine

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.