Epidemiology of Childhood Hyperthyroidism in France: A Nationwide Population-Based Study

The Journal of Clinical Endocrinology and Metabolism
Marie SimonJuliane Léger

Abstract

Hyperthyroidism affects all age groups, but epidemiological data for children are scarce. To perform a nationwide epidemiological survey of hyperthyroidism in children and adolescents. A cross-sectional descriptive study. Identification of entries corresponding to reimbursements for antithyroid drugs in the French national insurance database. All cases of childhood hyperthyroidism (6 months to 17 years of age) in 2015. National incidence rate estimated with a nonlinear Poisson model and spatial distribution of cases. A total of 670 cases of childhood hyperthyroidism were identified. Twenty patients (3%) had associated autoimmune or genetic disease, with type 1 diabetes and Down syndrome the most frequent. The annual incidence for 2015 was 4.58/100,000 person-years (95% CI 3.00 to 6.99/100,000). Incidence increased with age, in both sexes. This increase accelerated after the age of 8 in girls and 10 in boys and was stronger in girls. About 10% of patients were affected before the age of 5 years (sex ratio 1.43). There was an interaction between age and sex, the effect of being female increasing with age: girls were 3.2 times more likely to be affected than boys in the 10 to 14 years age group and 5.7 times more likely to be affe...Continue Reading

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Feb 12, 2019·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Vahab Fatourechi
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