Epidemiology of ciprofloxacin-resistant Pseudomonas aeruginosa in a veterans affairs hospital

American Journal of Therapeutics
W KhayrA Walters

Abstract

This study was performed to identify risk factors for the nosocomial acquisition of ciprofloxacin-resistant Pseudomonas aeruginosa (CRPA) in a Veterans Administration hospital between January 1994, and March 1995. The study was a retrospective comparison of host factors and in-hospital exposures of patients who acquired nosocomially CRPA and ciprofloxacin-sensitive P. aeruginosa (CSPA). Participants included 42 adult patients with nosocomial CRPA acquisition and 52 adult patients with nosocomial CSPA acquisition. Before pseudomonal acquisition, antecedent ciprofloxacin receipt (50% compared with 8%; odds ratio [OR], 12; p = 0.001), the presence of an indwelling airway (36% compared to 17%; OR, 2.6; p = 0.04), and documented antecedent infection (74% compared to 52%; OR, 2.6; p = 0.03) were significantly associated with acquisition of CRPA. On multivariate analysis, antecedent ciprofloxacin receipt (OR, 16.8; p = 0.0001) and presence of an indwelling airway (OR, 10.5; p = 0.009) remain as significant associations. Furthermore, the test of significance confirmed synergy between these two factors. Antecedent ciprofloxacin therapy and indwelling airway act independently and synergistically to promote CRPA acquisition.

Citations

Mar 17, 2005·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Cheol-In KangKang-Won Choe
Mar 19, 2015·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Valerie C CluzetDarren R Linkin

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