Epidemiology of Clostridium difficile in Germany based on a single center long-term surveillance and German-wide genotyping of recent isolates provided to the advisory laboratory for diagnostic reasons

International Journal of Medical Microbiology : IJMM
Lutz von MüllerMathias Herrmann

Abstract

Epidemiology of Clostridium difficile is characterized by worldwide increase of C. difficile infections (CDI) and the emergence of new epidemic outbreak strains with the capacity for global spreading. Long-term local surveillance at the University of Saarland Medical Center between 2000 and 2013 shows that the incidence rate of laboratory-confirmed CDI was influenced by local epidemiology as well as by testing strategies. Since 2008, molecular typing of C. difficile was regularly performed for symptomatic hospitalized patients by surface-layer protein A sequence typing (slpAST), which is an established highly standardized technique for genotyping of C. difficile. The results were assigned to known ribotypes for better comparison to international data. It could be demonstrated that distribution of genotypes was different between age groups. Older patients were predominantly infected with ribotype 001 and 027, whereas ribotype 027 was not detected in the pediatric population. Molecular typing of German isolates sent to the advisory laboratory between 2011 and 2013 revealed that ribotype 027 is present with high percentages in most German regions except for the very North. In conclusion, optimized testing of all hospitalized patie...Continue Reading

References

Jan 28, 2005·Journal of Medical Microbiology·Haru KatoYoshichika Arakawa
Oct 6, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jacques PépinLuc Lanthier
Mar 28, 2006·Lancet·Jane FreemanMark Wilcox
May 18, 2006·Emerging Infectious Diseases·Ed J KuijperDaan W Notermans
Dec 15, 2006·Journal of Clinical Microbiology·Renate J van den BergEd J Kuijper
Mar 11, 2008·Journal of Clinical Microbiology·Abraham GoorhuisEdward J Kuijper
Sep 24, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Abraham GoorhuisEd J Kuijper
Dec 3, 2008·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Ajay K SethiCurtis J Donskey
Feb 14, 2009·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Bettina WeissAndreas Jansen
Jul 18, 2009·International Journal of Antimicrobial Agents·Insa JoostLutz von Müller
Jun 17, 2009·Nature Reviews. Microbiology·Maja RupnikDale N Gerding
Mar 24, 2010·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Stuart H CohenUNKNOWN Infectious Diseases Society of America
Mar 31, 2010·Emerging Infectious Diseases·Nils Henning ZaissUlrich Nübel
Mar 11, 2011·Journal of Clinical Microbiology·Fred C TenoverDavid H Persing
Jun 15, 2011·The Journal of Infection·David A EnochJ Andreas Karas
Sep 15, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A GoorhuisE J Kuijper
Aug 28, 2012·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Konstantinos Z VardakasMatthew E Falagas
Nov 2, 2012·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·L von MüllerM Herrmann
Mar 28, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Rana E El Feghaly, Phillip I Tarr
Jun 4, 2013·Anaerobe·Mukil NatarajanDavid M Aronoff
Jun 20, 2013·JAMA Internal Medicine·Amit S ChitnisFernanda C Lessa
Oct 15, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S B DebastUNKNOWN European Society of Clinical Microbiology and Infectious Diseases
Mar 13, 2014·The Journal of Antimicrobial Chemotherapy·Petra GastmeierChristine Geffers
May 7, 2014·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Erik R DubberkeDale N Gerding

❮ Previous
Next ❯

Citations

Sep 14, 2015·International Journal of Medical Microbiology : IJMM·Ulrich VogelMary Slack
Apr 12, 2016·Anaerobe·Mardjan Arvand, Gudrun Bettge-Weller
Apr 20, 2016·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A SantosM Oleastro
Oct 30, 2016·International Journal of Medical Microbiology : IJMM·M KrutovaE J Kuijper
Oct 23, 2016·Infectious Diseases and Therapy·Christoph LübbertArne C Rodloff
Dec 18, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sofie M van DorpEd J Kuijper
Feb 6, 2018·Annals of Laboratory Medicine·Nobuaki Mori, Takashi Takahashi
Mar 24, 2016·World Journal of Gastroenterology : WJG·Lynne Vernice McFarlandShan Goh
Feb 28, 2017·Antimicrobial Resistance and Infection Control·Jacqueline FärberGernot Geginat
Aug 31, 2017·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·Sabine GleichBertrand Hirl
Apr 30, 2021·International Journal of Medical Microbiology : IJMM·Ahmed Mohamed Mostafa AbdrabouFabian K Berger
Aug 10, 2021·Infection Prevention in Practice·Vanda Marujo, Mardjan Arvand

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
Lutz von MüllerMathias Herrmann
European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
C IlchmannH Rohde
International Journal of Antimicrobial Agents
Insa JoostLutz von Müller
The Korean journal of laboratory medicine
Heejung KimYunsop Chong
© 2021 Meta ULC. All rights reserved