Epidemiology of driver mutations in lung cancer in a German tertiary hospital in patients with testing indication

Personalized Medicine
Verena SchildgenMichael Brockmann

Abstract

KRAS, BRAF, EGFR and ALK-mutation testing is a prerequisite for non-small-cell lung cancer treatments, but there remains limited epidemiological information about such mutations in German cohorts. Between February 2010 and June 2015, a total of 1080 tumor samples from 1019 non-small-cell lung cancer patients were analyzed for KRAS, BRAF, EGFR and ALK-mutations by Therascreen-pyrosequencing and FISH. Mutation patterns differed dependent on the histological subtype and sex. Mainly, adenocarcinomas were mutated and formed the major histological group. Double mutations were observed also not explicitly screened for. In our German cohort, female adenocarcinoma patients had statistically significantly higher rates EGFR mutations than male patients. The different mutation patterns dependent on histological phenotypes warrant further epidemiological studies while suggesting different mechanisms of cancerogenesis.

References

Aug 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·William PaoHarold Varmus
Jun 2, 2009·Nature Reviews. Clinical Oncology·Helena LinardouSamuel Murray
Jun 29, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G D'AddarioUNKNOWN ESMO Guidelines Working Group
Oct 29, 2010·The New England Journal of Medicine·Eunice L KwakA John Iafrate
Feb 26, 2011·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayDonald Maxwell Parkin
Jul 8, 2011·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Kimberly J GordenJill M Kolesar
Dec 6, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Erik ThunnissenFlorian Laenger
Jan 28, 2012·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Wolfram Brugger, Michael Thomas
Feb 2, 2013·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·Verena SchildgenMichael Brockmann
Feb 13, 2013·Cancer·Verena Schildgen, Oliver Schildgen
Jun 4, 2013·The New England Journal of Medicine·Alice T ShawPasi A Jänne
Jun 5, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Justin F GainorAlice T Shaw
Jun 19, 2013·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Solange PetersRolf Stahel
Aug 13, 2013·Expert Opinion on Biological Therapy·Gabriele MinutiFederico Cappuzzo
Aug 30, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Maximilian von LaffertManfred Dietel
Nov 11, 2014·Expert Opinion on Pharmacotherapy·Aswin SomasundaramTimothy F Burns
Feb 14, 2015·Applied Immunohistochemistry & Molecular Morphology : AIMM·Verena SchildgenErich Stoelben
May 13, 2015·Nature Reviews. Clinical Oncology·Anish ThomasGiuseppe Giaccone

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved