Epidemiology of Epstein-Barr virus infection and infectious mononucleosis in the United Kingdom

BMC Public Health
A. KuriRuth Dobson

Abstract

Epstein-Barr Virus (EBV) is a ubiquitous gamma-herpesvirus with which ~ 95% of the healthy population is infected. EBV infection has been implicated in a range of haematological malignancies and autoimmune diseases. Delayed primary EBV infection increases the risk of subsequent complications. Contemporaneous seroepidemiological data is needed to establish best approaches for successful vaccination strategies in the future. We conducted a sero-epidemiological survey using serum samples from 2325 individuals between 0 and 25 years old to assess prevalence of detectable anti-EBV antibodies. Second, we conducted a retrospective review of Hospital Episode Statistics to examine changes in Infectious Mononucleosis (IM) incidence over time. We then conducted a large case-control study of 6306 prevalent IM cases and 1,009,971 unmatched controls extracted from an East London GP database to determine exposures associated with IM. 1982/2325 individuals (85.3%) were EBV seropositive. EBV seropositivity increased more rapidly in females than males during adolescence (age 10-15). Between 2002 and 2013, the incidence of IM (derived from hospital admissions data) increased. Exposures associated with an increased risk of IM were lower BMI, White...Continue Reading

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Citations

Jan 5, 2021·Frontiers in Immunology·Gunnar HouenJette Lautrup Frederiksen
Jun 22, 2021·Journal of Immunoassay & Immunochemistry·Carlos Eduardo de Castro AlvesGemilson Soares Pontes
Aug 1, 2021·International Journal of Clinical Practice·Elisabeth J KapKarel Kostev
Aug 26, 2021·Global Medical Genetics·Darja Kanduc
Sep 30, 2021·Nature Reviews. Neurology·Nils Koch-Henriksen, Melinda Magyari
Oct 6, 2021·Laboratory Investigation; a Journal of Technical Methods and Pathology·Paul J HansonBruce M McManus
Nov 24, 2021·MMW Fortschritte der Medizin·Florian E Gottwald, Johannes R Bogner
Dec 2, 2021·Journal of Medical Virology·Zhuo LiYang Han

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Methods Mentioned

BETA
ELISA

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