PMID: 8963029Sep 1, 1995Paper

Epidemiology of genotypes of hepatitis C virus in Japanese patients with type C chronic liver diseases: a multi-institution analysis

Journal of Gastroenterology and Hepatology
G YamadaK Hino

Abstract

Sixteen medical institutions in Japan collaborated in this study of the epidemiology of hepatitis C virus (HCV) genotypes. A total of 4176 patients with type C chronic liver disease, from the four main islands of Japan, were evaluated. Of those evaluated, 2794 had chronic hepatitis, 727 had liver cirrhosis and 655 had hepatocellular carcinoma. The HCV genotype of the patients was determined by an enzyme-linked immunosorbent assay based on serological genotype 1- and 2-specific recombinant peptides (SG-1 and SG-2, respectively) of the NS4 region. The prevalence of SG-1 and SG-2 HCV was similar in the four main islands of Japan. SG-1 HCV predominated in each disease category (69-76%). The percentage of patients with SG-1 HCV increased by 7%, while that of patients with SG-2 HCV decreased by 7%, as liver disease progressed in severity from chronic hepatitis to carcinoma (P < 0.001). Patients with either SG-1 or SG-2 had a similar mean age and history of blood transfusion. In conclusion, SG-1 HCV was found to predominate in Japan, and the HCV genotype was found to be related to the stage of hepatitis C disease.

References

May 1, 1975·The Journal of Infectious Diseases·Y YamishitaM Mayumi
Feb 28, 1992·Biochemical and Biophysical Research Communications·S MoriK Shimotohno
May 1, 1992·The Journal of General Virology·S W ChanP Simmonds
Aug 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K YoshiokaT Morishima
Aug 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·T A ChaM S Urdea
Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·G InchauspeA M Prince
Jul 1, 1991·Virus Genes·K Tsukiyama-KoharaA Nomoto
Jan 1, 1991·Journal of Hepatology·H T CuypersA Weiner
Sep 1, 1991·The Journal of General Virology·T NakaoT Date
Aug 16, 1990·Biochemical and Biophysical Research Communications·N EnomotoT Date
Oct 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K KiyosawaR H Purcell
May 18, 1989·Nature·S Kwok, R Higuchi
Jun 1, 1971·The Journal of Infectious Diseases·G L Le Bouvier
Feb 20, 1993·Lancet·S BrillantiL Barbara
Mar 1, 1993·Journal of Gastroenterology and Hepatology·K ChayamaS Koyama

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Citations

Aug 1, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E TanakaH J Alter
Mar 1, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hidenori ToyodaHidemi Goto
Jan 7, 1999·The Pediatric Infectious Disease Journal·T TagaM Shimada
May 30, 2008·The Tohoku Journal of Experimental Medicine·Junichiro NakamuraKouhei Akazawa
Apr 15, 2006·International Journal of Medical Sciences·Theodore Sy, M Mazen Jamal
Feb 1, 2014·International Journal of Cancer. Journal International Du Cancer·Mei-Hsuan LeeUNKNOWN REVEAL-HCV Study Group
Feb 19, 2010·Journal of Medical Virology·Kazuya ShiogamaYutaka Tsutsumi
Nov 25, 2004·Clinics in Liver Disease·L B Seeff
Mar 10, 2001·The Journal of Laboratory and Clinical Medicine·H A Nguyen, S B Ho
Nov 26, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C NiederauD Häussinger
Aug 2, 2000·Journal of Gastroenterology and Hepatology·H Yatsuhashi, M Yano
Jul 1, 1997·Journal of Gastroenterology and Hepatology·T IchijoE Tanaka
Feb 9, 2000·Japanese Journal of Cancer Research : Gann·J MuraseH Kinoshita
Dec 22, 1999·The Tohoku Journal of Experimental Medicine·E YoshiiM Mizokami
Jan 25, 2005·Vox Sanguinis·H MurokawaUNKNOWN Japanese Red Cross NAT Screening Research Group

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