Epidemiology of Hemostatic Transfusions in Children Supported by Extracorporeal Membrane Oxygenation.

Critical Care Medicine
Oliver KaramMarianne E Nellis

Abstract

To evaluate the epidemiology of hemostatic transfusions (plasma, platelet, and cryoprecipitate) in children supported by extracorporeal membrane oxygenation. Secondary analysis of a large observational cohort study. Eight pediatric institutions within the Eunice Kennedy Shriver National Institute of Child Health and Human Development's Collaborative Pediatric Critical Care Research Network. Critically ill children supported by extracorporeal membrane oxygenation. None. Extracorporeal membrane oxygenation was used in the care of 514 consecutive children. Platelets were transfused on 68% of extracorporeal membrane oxygenation days, plasma on 34% of the days on extracorporeal membrane oxygenation, and cryoprecipitate on 14%. Only 24% of the days on extracorporeal membrane oxygenation were free of any hemostatic transfusions. Daily platelet transfusion dose was independently associated with chest tube output (p < 0.001), other bleeding requiring RBC transfusion (p = 0.03), and daily set platelet goal (p = 0.009), but not with total platelet count (p = 0.75). Daily plasma transfusion dose was independently associated with chest tube output (p < 0.001), other bleeding requiring RBC transfusion (p = 0.01), activated clotting time (p =...Continue Reading

References

Jun 17, 2004·British Journal of Haematology·D F O'ShaughnessyUNKNOWN British Committee for Standards in Haematology, Blood Transfusion Task Force
Feb 19, 2014·Critical Care Medicine·Robert I Parker
Feb 4, 2015·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Heidi J DaltonUNKNOWN Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Resear
Feb 5, 2015·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·David K WerhoUNKNOWN Extracorporeal Life Support Organization Member Centers
Apr 11, 2015·American Journal of Respiratory and Critical Care Medicine·Oliver KaramUNKNOWN PlasmaTV Investigators
Mar 23, 2017·American Journal of Respiratory and Critical Care Medicine·Heidi J DaltonUNKNOWN Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Resear
May 5, 2018·Critical Care Medicine·Marianne E NellisUNKNOWN Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) network, Pediatric Critical Care Blood Research Network (Blood
Aug 27, 2019·Critical Care Medicine·Marianne E NellisUNKNOWN PediECMO Investigators
Sep 14, 2019·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Jamie S PenkHeidi J Dalton
Oct 1, 2019·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Katherine CashenUNKNOWN Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Resear
Oct 24, 2019·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Marianne E NellisUNKNOWN Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network, Pediatric Critical Care Blood Research Network (Blood

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