Epidemiology of highly endemic multiply antibiotic-resistant shigellosis in children in the Peruvian Amazon.

Pediatrics
Margaret KosekEric Hall

Abstract

Our goal was to estimate the impact of a Shigella vaccine in an area where shigellosis is endemic by characterizing the disease burden and antibiotic-resistance profiles of isolates and by determining the prevalence of Shigella flexneri serotypes. We conducted a 43-month-long prospective, community-based diarrheal disease surveillance in 442 children <72 months of age in the Peruvian Amazon between October 1, 2002, and April 15, 2006. The incidence of diarrheal disease was 4.38 episodes per child-year. The incidence rate for shigellosis was 0.34 episodes per child-year in children <72 months of age and peaked in children between 12 and 23 months at 0.43 episodes per child-year. Maternal education at or beyond the primary grade level, piped water supply, weight-for-age z score, and improved water-storage practices were the most significant determinants of disease in this community with living conditions comparable to many rural areas in the developing world. Children living in this region had a 20-fold higher rate of disease incidence detected by active surveillance as those recently estimated by passive detection. Most symptomatic disease was caused by S flexneri, although the diversity of serotypes will require a multivalent v...Continue Reading

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Citations

Jan 20, 2012·International Journal of Epidemiology·Gwenyth LeeMargaret Kosek
Jun 6, 2012·The American Journal of Tropical Medicine and Hygiene·Margaret KosekGraciela Meza Sanchez
Aug 12, 2014·Current Tropical Medicine Reports·Mussaret Bano Zaidi, Teresa Estrada-García
Nov 2, 2014·The Pediatric Infectious Disease Journal·Gwenyth LeeMargaret Kosek
Jun 1, 2014·The Pediatric Infectious Disease Journal·Sylvia Becker-DrepsMargarita Paniagua
Feb 25, 2014·Epidemiology and Infection·D CohenT Shohat
Oct 12, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Pablo Peñataro YoriMargaret Kosek
Jul 29, 2009·The Pediatric Infectious Disease Journal·Pablo Peñataro YoriMargaret Kosek
Aug 7, 2010·Current Opinion in Infectious Diseases·Margaret KosekMaribel Paredes Olortegui
Jan 24, 2012·The Journal of Infection·Margaret L PfeifferTheresa J Ochoa
May 23, 2015·International Journal of Medical Microbiology : IJMM·Angela LluqueJoaquim Ruiz
Aug 17, 2016·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Kenia Barrantes, Rosario Achí
Oct 14, 2016·BMC International Health and Human Rights·Gwenyth O LeeMargaret Kosek
Nov 15, 2008·Acta Tropica·Daniela M L Mota-FerreiraJulia M Costa-Cruz
Oct 15, 2014·The American Journal of Tropical Medicine and Hygiene·Christine Marie GeorgeErik D Lindquist
Jul 16, 2015·The American Journal of Tropical Medicine and Hygiene·Jessica D RothsteinMargaret Kosek
Aug 6, 2010·The Cochrane Database of Systematic Reviews·Prince Rh ChristopherVenkatesan Sankarapandian
Apr 25, 2019·The American Journal of Tropical Medicine and Hygiene·Anika LarsonDaniel Mäusezahl
Dec 17, 2015·BMC Research Notes·Atsebaha Gebrekidan Kahsay, Zelalem Teklemariam
Aug 9, 2019·The American Journal of Tropical Medicine and Hygiene·Jesús D RojasFrédéric M Poly
Feb 6, 2013·PLoS Neglected Tropical Diseases·Gwenyth LeeMargaret Kosek
Dec 10, 2020·Access Microbiology·Ramya RaghavanJharna Mandal
Jul 16, 2021·Current Opinion in Infectious Diseases·James A Platts-Mills, Elizabeth T Rogawski McQuade

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