PMID: 9557725Apr 29, 1998Paper

Epidemiology of infection with Epstein-Barr virus types 1 and 2: lessons from the study of a T-cell-immunocompromised hemophilic cohort

Journal of Virology
Q Y YaoA B Rickinson

Abstract

In apparent contrast to earlier work on Epstein-Barr virus (EBV) carriage in the general Caucasian population, in vitro virus isolations from human immunodeficiency virus (HIV)-positive male homosexual cohorts have shown frequent examples of multiple EBV infection and an overall prevalence of type 2 EBV strains exceeding 30%. Here we ask to what extent these findings might hold true in another T-cell-immunocompromised cohort, HIV-positive hemophilic patients. Resident EBV strains were rescued within lymphoblastoid cell lines derived from the blood and throat washings of 39 such individuals, using the same in vitro protocols of virus isolation as for the homosexual cohort. A mean of 19 independent cell lines was made per patient, and in each case the resident virus was characterized by PCR-based viral genomic analysis and by immunoblotting to reveal the viral "EBNAprint." By these criteria a significant proportion (14 of 39) of the hemophilic cohort carried more than one EBV strain, suggesting that T-cell impairment does indeed sensitize virus carriers to reinfection with new strains of exogenously transmitted virus. However, the overall incidence of type 2 EBV infection was 10%, which is close to that observed in the earlier wo...Continue Reading

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Jan 23, 1999·Current Opinion in Hematology·D E Mosier
Jun 30, 2005·Transplant Infectious Disease : an Official Journal of the Transplantation Society·E MeijerL F Verdonck
Jan 11, 2000·Journal of Virology·R S MidgleyS P Lee
Mar 27, 2001·Journal of Virology·S NikiforowG Miller
May 19, 2017·Journal of Virology·Samantha CorreiaPaul J Farrell
Jan 24, 2002·AIDS Research and Human Retroviruses·Lucia FassoneLuigi Maria Larocca
Feb 22, 2007·Journal of Medical Virology·Rita Mariel CorreaMaría Alejandra Picconi
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Jul 9, 2014·Revista da Associação Médica Brasileira·Larissa SantosLedy Oliveira
Aug 17, 2020·Journal of Virology·Xiaofan LiSumita Bhaduri-McIntosh
Jul 28, 2018·PLoS Pathogens·Jillian A BristolShannon C Kenney
Mar 27, 2001·International Journal of Cancer. Journal International Du Cancer·S HenryB Mariame

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