Epidemiology of Inflammatory Bowel Disease in India: The Great Shift East

Inflammatory Intestinal Diseases
Saurabh Kedia, Vineet Ahuja

Abstract

Inflammatory bowel disease (IBD), once considered to be a Western disease, is increasingly being reported from India and other Asian countries. The present review summarizes epidemiology and disease characteristics of IBD in India with reference to other Asian countries and the West. India is projected to have one of the highest disease burden of IBD across the globe. The overall genetic risk and microbial signature in Indian IBD patients are similar to those of patients in the West as demonstrated by the similar incidence of IBD in second-generation Indian immigrants and matching perturbations in the structural and functional component of gut microbiota in Indian studies. The concept of the hygiene hypothesis continues to remain controversial with Indian studies demonstrating contradictory findings. The disease characteristics, long-term outcomes including the risk of colorectal cancer, and the effect of pregnancy on IBD and vice versa in Indian patients with IBD are in general similar with few differences. Unlike patients in the West, very few Indian patients have a positive family history. The Indian disease pattern is going through a phase of epidemiological transition with a surge in the incidence of IBD. The epidemiology ...Continue Reading

Citations

Jan 16, 2019·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Nagesh KamatVineet Ahuja
Oct 9, 2019·Journal of Biochemical and Molecular Toxicology·Gang GuoJunjun She
Nov 27, 2019·Journal of Clinical Gastroenterology·Rupa BanerjeeCharles N Bernstein
Aug 17, 2020·European Journal of Gastroenterology & Hepatology·Anshu SrivastavaSurender Kumar Yachha
Jun 28, 2018·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Saurabh Kedia, Vineet Ahuja
Sep 18, 2017·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Sanjeevani K TomarNamrata Singh
Feb 23, 2019·Indian Journal of Pediatrics·Devasenathipathy KandasamyArun Kumar Gupta
Sep 12, 2020·Nature Reviews. Disease Primers·Taku KobayashiToshifumi Hibi
Aug 28, 2020·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Bhavik Bharat Shah, Mahesh Kumar Goenka
Oct 12, 2020·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Sudheer K VuyyuruVineet Ahuja
Oct 10, 2020·Nature Reviews. Gastroenterology & Hepatology·Gilaad G Kaplan, Joseph W Windsor
Feb 3, 2021·Yonsei Medical Journal·Jihye Park, Jae Hee Cheon
Feb 9, 2021·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Saurabh Kedia, Vineet Ahuja
Apr 17, 2021·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Sudheer K VuyyuruVineet Ahuja
Jun 5, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Raquel LinaresRubén Francés
Aug 19, 2020·Intestinal research·Ajit SoodDharmatma Singh
Oct 10, 2021·The Lancet. Gastroenterology & Hepatology·Tina Aswani-OmprakashShaji Sebastian
Sep 29, 2019·Inflammatory Intestinal Diseases·Philipp SchreinerGerhard Rogler
Aug 13, 2021·The Indian Journal of Medical Research·Mayank Jain, Jayanthi Venkataraman

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