Epidemiology of insulin-like growth factor-I in elderly men and women. The Rancho Bernardo Study

American Journal of Epidemiology
D Goodman-Gruen, E Barrett-Connor

Abstract

Insulin-like growth factor-I (IGF-I) is abundant in the circulation and has been shown to have a wide array of biologic effects. The authors carried out a cross-sectional community-based study of 420 men and 419 nonestrogen-using postmenopausal women aged 50-97 years to ascertain the within-person and laboratory reliability of IGF-I measurements, and the association of IGF-I with common epidemiologic confounders. There was no evidence of seasonal or diurnal variation. IGF-I decreased linearly with age in both sexes, with significantly higher levels in men than women (134.1 microg/liter vs. 126.9 microg/liter; p = 0.03) [corrected]. In age-adjusted analyses, IGF-I was not associated with height, total or central body fat, lean body mass, current smoking, physical activity, or commonly used medications. By contrast, in both men and women who reported any alcohol use, IGF-I levels were significantly higher compared with those in men and women who reported no alcohol use, and alcohol as a continuous variable showed a significant positive linear trend in men (p = 0.0007). The authors conclude that IGF-I varied significantly only with age, sex, and alcohol use. The minimal number of confounding variables, good reliability, and little...Continue Reading

Citations

Sep 19, 2002·International Journal of Cancer. Journal International Du Cancer·Annekatrin LukanovaRudolf Kaaks
May 15, 2001·International Journal of Cancer. Journal International Du Cancer·A LukanovaR Kaaks
Dec 21, 2004·Angiogenesis·David C SaneK Bridget Brosnihan
May 6, 2009·Cancer Causes & Control : CCC·Sharon SaydahNancy Potischman
Jul 21, 2011·Cancer Causes & Control : CCC·Wildon R FarwellJ Michael Gaziano
Dec 21, 2011·Cancer Causes & Control : CCC·Mari-Anne RowlandsRichard M Martin
Jul 20, 2002·The Journal of Steroid Biochemistry and Molecular Biology·Svein I HellePer E Lønning
Aug 30, 2000·Annals of Epidemiology·S D PutnamC F Lynch
Aug 14, 2003·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Anders Juul
Nov 15, 2001·Joint, Bone, Spine : Revue Du Rhumatisme·R RizzoliJ P Bonjour
Feb 20, 2010·Journal of Human Genetics·Chang-Ming GaoKazuo Tajima
Aug 11, 2006·European Journal of Clinical Nutrition·T NoratR Kaaks
Feb 15, 2007·European Journal of Clinical Nutrition·R M MartinD Gunnell
Mar 23, 2006·International Journal of Obesity : Journal of the International Association for the Study of Obesity·I T GramR Kaaks
Mar 3, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Marcello MaggioE Jeffrey Metter
Jun 24, 1998·Journal of the National Cancer Institute·A WolkD Trichopoulos
May 28, 2013·Journal of the National Cancer Institute·Roland B WalterEmily White
Aug 23, 2000·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·C La VecchiaE Negri
Feb 26, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Aimee A D'AloisioDonna D Baird
May 27, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Loïc Le MarchandRobert Decker
Apr 10, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Carolyn S P LamRamachandran S Vasan
Nov 17, 1998·American Journal of Respiratory and Critical Care Medicine·S T UhD W Riches
Dec 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Brian M WolpinCharles S Fuchs
May 6, 2004·The Journal of Clinical Endocrinology and Metabolism·Daniela MilaniDavid L Kleinberg
Mar 30, 2000·Aging : Clinical and Experimental Research·M BonnefoyJ R Lacour
May 15, 2013·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Marcello MaggioGian Paolo Ceda

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