Feb 20, 1998

Epidemiology of invasive pneumococcal disease in the Western Region, The Gambia

The Pediatric Infectious Disease Journal
S UsenB M Greenwood

Abstract

Streptococcus pneumoniae is a major cause of morbidity and mortality in young children in the developing world. The recent development of pneumococcal polysaccharide/protein conjugate vaccines may make possible prevention of this infection. However, little is known about the epidemiology of invasive pneumococcal disease in children in the developing world. To determine the incidence and epidemiologic features of invasive pneumococcal disease in children resident in a semiurban area of The Gambia. The study was part of a large trial of an Haemophilus influenzae type b vaccine that recruited 42 848 children at the age of 2 months during the period March, 1993, to October, 1995. Follow-up of study children continued until December 31, 1995; therefore the first children to enter the trial were followed for 2.5 years and the last for just a few months. During the period of surveillance, 2256 children were investigated for possible invasive pneumococcal disease when they presented to a hospital or health center. We detected 110 cases of pneumococcal disease. Pneumonia was the most common form of invasive pneumococcal disease observed (75.5% of patients). The incidence of pneumococcal disease was 224 [95% confidence interval (CI) 171,...Continue Reading

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  • Citations53

Mentioned in this Paper

Haemophilus influenzae a, capsular polysaccharide vaccine
Meningitis, Haemophilus
Haemophilus Vaccines
Polysaccharides, Bacterial
Pneumococcal Infections
Pneumonia
Bacterial Capsules
Invasive Pneumococcal Disease, Recurrent Isolated,1
Bacterial Infections

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