Epidemiology of non-alcoholic fatty liver disease in Asia.

Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology
Sui-Weng Wong, Wah-Kheong Chan

Abstract

The growing burden of non-alcoholic fatty liver disease (NAFLD) parallels the increasing prevalence of obesity in Asia. The overall prevalence of NAFLD in Asia is now estimated to be 29.6% and may have surpassed that in Western populations. NAFLD increases with increasing age and is closely associated with metabolic syndrome. Ethnic differences exist in the prevalence of NAFLD, but the underlying factors are unclear. There were initial concerns about lean NAFLD being associated with more severe liver disease and increased mortality, but subsequent studies suggested otherwise. Only some NAFLD patients progress to develop advanced liver fibrosis and cirrhosis, while the liver status remains unchanged in the majority; fibrosis stage is the most important predictor of disease-specific mortality in NAFLD. Surveillance for hepatocellular carcinoma (HCC) remains a challenge due to undiagnosed cirrhosis and the development of HCC in non-cirrhotic NAFLD patients. Diabetes mellitus shares a bidirectional relationship with NAFLD; NAFLD is highly prevalent among patients with diabetes mellitus, and diabetes mellitus is associated with more severe NAFLD. Chronic hepatitis B (CHB) is a major cause of chronic liver disease in Asia; NAFLD and ...Continue Reading

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Citations

Sep 5, 2020·Drug Design, Development and Therapy·Xinxu ZhangYing Pu
Jan 8, 2021·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Sushmita RaiUday C Ghoshal
Feb 3, 2021·Clinical Therapeutics·Wei-Kei Wong, Wah-Kheong Chan
Nov 19, 2020·Gastroenterology Research and Practice·A Sirinawasatien, T Techasirioangkun
Jan 26, 2021·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·M Masudur RahmanMahmud Hasan
Mar 28, 2021·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Chandan Kumar KedarisettyShiv Kumar Sarin
Aug 11, 2021·Journal of Digestive Diseases·Shu Jing XiaJian Gao Fan

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