Epidemiology of non-B clade forms of HIV-1 in men who have sex with men in the UK.

AIDS
Julie FoxUK Collaborative Group on HIV Drug Resistance

Abstract

To describe the frequency and risk factors of non-B HIV-1 subtypes in men who have sex with men (MSM) in the UK. Observational study. MSM diagnosed with HIV-1 infection from 1980-2007, with HIV genotype held in the UK HIV Drug Resistance Database were identified. Protease and reverse transcriptase sequences were collected and viral clade determined using the REGA algorithm. Associations between demographic variables and subtype were analysed using logistic regression. The prevalence of non-B HIV-1 infection amongst MSM in the UK was 5.4% (437/8058). In the UK this increased with year of diagnosis from pre1996 to 2002, and has subsequently remained relatively stable at around 7-9% after 2002, with a recent increase in 2007 to 13%. Multivariate analysis showed that acquisition of non-B HIV-1 infection was independently associated with later year of HIV diagnosis (P < 0.001), black ethnicity (P < 0.001) and non-European country of birth (P = 0.01). Age was also associated with subtype with individuals aged 25-39 years being less likely to have non-B virus than those aged less than 25 years (P = 0.01). Restricting the analysis to white men born in the UK, the association between subtype and year of diagnosis remained statistically ...Continue Reading

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Citations

May 4, 2012·Cold Spring Harbor Perspectives in Medicine·Sten H Vermund, Andrew J Leigh-Brown
Mar 19, 2013·AIDS Research and Human Retroviruses·Fransje A KoningPatricia A Cane
Dec 26, 2015·The Journal of Infectious Diseases·Manon Ragonnet-CroninUNKNOWN UK HIV Drug Resistance Database
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Jun 15, 2011·Antiviral Research·Federico GarcíaUNKNOWN Cohort of the Spanish AIDS Research Network (CoRIS)

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