Epidemiology of orofacial clefts in a Danish county over 35 years - Before and after implementation of a prenatal screening programme for congenital anomalies

European Journal of Medical Genetics
Eva Berenth Paaske, Ester Garne

Abstract

In 2004 the Danish National Board of Health changed its screening recommendations. Since 2005 a first trimester screening for Down syndrome and a prenatal ultrasound screening for congenital anomalies in the second trimester of pregnancy has been offered to all pregnant women. The aim of this study was to describe the prevalence of cleft lip with or without cleft palate and cleft palate in a Danish area and to describe associated anomalies and the development in prenatal diagnosis over time. The study was based on data from the EUROCAT Registry for Funen County. The registry is based on multiple data sources and includes information about live births, fetal deaths with a gestational age >20 weeks and terminations of pregnancy after prenatal diagnosis of severe fetal anomaly. The study included all fetuses/infants out of a population of 182,907 births diagnosed with orofacial clefts born between 1980 and 2014. There were 271 cases diagnosed with cleft lip with or without cleft palate and 127 cases diagnosed with cleft palate, giving a prevalence of 14.8 per 10,000 births for cleft lip with or without cleft palate and 6.9 per 10,000 births for cleft palate. There were no significant changes in prevalence over time for the two ano...Continue Reading

Citations

Mar 26, 2019·American Journal of Medical Genetics. Part a·R Brian LowryBarbara Sibbald
Jun 20, 2019·Journal of Applied Oral Science : Revista FOB·Jorge Tomasio CaballeroSimone Soares
May 26, 2021·Journal of Stomatology, Oral and Maxillofacial Surgery·Nader SalariMasoud Mohammadi

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