Epidemiology of Pediatric NMOSD in Germany and Austria

Frontiers in Neurology
Christian LechnerKevin Rostásy

Abstract

Background: Neuromyelitis optica spectrum disorders (NMOSD) are severe inflammatory demyelinating disorders of the central nervous system mainly characterized by recurrent episodes of uni- or bilateral optic neuritis (ON), transverse myelitis (TM) and brainstem syndromes (BS). The majority of adult patients has serum antibodies directed against the water channel protein aquaporin 4 (AQP4-abs). In pediatric patients, AQP4-abs are less, while antibodies against myelin oligodendrocyte glycoprotein (MOG-abs) are more frequently detectable than in adults. Some children with NMOSD have neither AQP4- nor MOG-ab (double-seronegative). Objective: Evaluation of epidemiological data regarding incidence and prevalence of pediatric NMOSD in Germany and Austria. Methods: We recruited pediatric NMOSD patients between 1 March 2017 and 28 February 2019 with five different tools: (1) ESPED (Surveillance Unit for Rare Pediatric Disorders in Germany), (2) ESNEK (Surveillance for Rare Neurological Disorders during Childhood), (3) pediatric neurology working group within the Austrian Society of Pediatrics and Adolescent Medicine, (4) BIOMARKER Study and (5) NEMOS (Neuromyelitis optica Study Group). We requested data regarding clinical symptoms, anti...Continue Reading

References

Feb 3, 2006·Annals of Neurology·Brian G WeinshenkerVanda A Lennon
May 24, 2006·Neurology·D M WingerchukB G Weinshenker
Feb 9, 2007·Neurology·S JariusA Vincent
Jun 15, 2007·Archives of Neurology·Brian G Weinshenker
Jun 15, 2007·Archives of Neurology·Steven L Galetta, Jeffrey Bennett
Mar 8, 2008·Current Treatment Options in Neurology·Dean M Wingerchuk, Brian G Weinshenker
Oct 8, 2008·Pediatrics·Timothy E LotzeJill V Hunter
Nov 10, 2010·Neurology·P HuppkeJ Gärtner
Jul 26, 2012·Multiple Sclerosis : Clinical and Laboratory Research·K-H ChangL-S Ro
Sep 22, 2012·Journal of the Neurological Sciences·Hideki HouzenHidenao Sasaki
Dec 22, 2012·Multiple Sclerosis : Clinical and Laboratory Research·K RostásyM Reindl
Jan 17, 2013·Journal of Neuroinflammation·Sven Jarius, Brigitte Wildemann
Oct 18, 2013·Pediatric Neurology·Yara Dadalti FragosoJorge M B Souza
Nov 26, 2013·Journal of Neurology·Corinna TrebstUNKNOWN Neuromyelitis Optica Study Group (NEMOS)
Jan 15, 2014·Neurology·Douglas Kazutoshi SatoKazuo Fujihara
Feb 5, 2014·Multiple Sclerosis : Clinical and Laboratory Research·Lekha Pandit, Rashmi Kundapur
Jun 21, 2014·Multiple Sclerosis : Clinical and Laboratory Research·Masoud EtemadifarZahra Nasr
Aug 6, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·Michael AbsoudJacqueline Palace
Oct 26, 2014·Multiple Sclerosis : Clinical and Laboratory Research·Romana HöftbergerAlbert Saiz
Mar 24, 2015·Neurology. Neuroimmunology and Neuroinflammation·Yael HacohenPatrick Waters
Apr 19, 2015·Journal of Neuroinflammation·Anne-Katrin PröbstelTobias Derfuss
May 15, 2015·Multiple Sclerosis International·Masoud EtemadifarReza Vosoughi
Jun 21, 2015·Neurology·Dean M WingerchukUNKNOWN International Panel for NMO Diagnosis
Dec 10, 2015·Journal of Neurology, Neurosurgery, and Psychiatry·Christian LechnerKevin Rostásy
Apr 27, 2016·Journal of Neurology, Neurosurgery, and Psychiatry·Patrick WatersRomain Marignier
Aug 25, 2016·Multiple Sclerosis : Clinical and Laboratory Research·Shahd Hm HamidAnu Jacob
Oct 1, 2014·Clinical & Experimental Neuroimmunology·Patrick J WatersDean M Wingerchuk
May 28, 2017·Journal of Neurology, Neurosurgery, and Psychiatry·Wajih BukhariSimon A Broadley
Aug 5, 2017·Neurology·Eva-Maria HennesUNKNOWN BIOMARKER Study Group
Sep 1, 2017·Neuropediatrics·Eva-Maria HennesKevin Rostásy
Oct 6, 2017·Multiple Sclerosis Journal - Experimental, Translational and Clinical·M P AlvarengaRm Papais Alvarenga
Oct 7, 2017·Multiple Sclerosis : Clinical and Laboratory Research·Maria SepúlvedaAlbert Saiz
Apr 26, 2018·Clinical Epidemiology·Magnus Spangsberg BoesenLau Caspar Thygesen
May 4, 2018·Current Treatment Options in Neurology·Grace Y Gombolay, Tanuja Chitnis
Nov 9, 2018·Frontiers in Neurology·Nadja BorisowFriedemann Paul

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Citations

Jul 3, 2021·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Ismail Solmaz, Banu Anlar
Aug 14, 2021·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·M A Sherman, A N Boyko

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Software Mentioned

ESPED
ESNEK
SPSS
BIOMARKER
NEMOS

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