Abstract
Although the majority of pneumococcal infections occur in the developing world, pneumococcal epidemiology is poorly understood in these settings. The aim of the study was to investigate the epidemiology of pneumococcal carriage among children younger than 5 years at a paediatric healthcare centre in Ghana. Four-hundred and twenty-three children were randomly sampled and nasopharyngeal specimens were collected from them. The specimens were cultured for Streptococcus pneumoniae, and the isolates were subjected to antibiotic susceptibility testing and serotyping by latex agglutination. Epidemiological data on demographic and clinical features of the study subjects were collected. The prevalence of pneumococcal carriage was 48.9% (207/422), with age groups 43-48 months having the highest carriage prevalence. In the multivariate analysis, pneumococcal carriage was significantly associated with runny nose (odds ratio = 1.9, p = 0.003) and day-care attendance (odds ratio = 1.5, p = 0.04). No pneumococcal resistance was observed for ceftriaxone, while the prevalence of resistance to the other antibiotics tested was: cotrimoxazole 100%, ampicillin 88%, tetracycline 78%, penicillin 63% and erythromycin 24%. Fourteen different pneumococca...Continue Reading
References
Sep 1, 1991·Molecular Microbiology·T J CoffeyJ M Musser
Jun 1, 1995·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Y ChongJ Henrichsen
Oct 1, 1995·Journal of Clinical Microbiology·J Henrichsen
Oct 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P C AppelbaumM R Jacobs
Feb 15, 2003·The Pediatric Infectious Disease Journal·Katherine L O'BrienUNKNOWN World Health Organization Pneumococcal Vaccine Trials Carriage Working Group
Feb 1, 1955·Journal of Clinical Pathology·E F BOWERS, L R JEFFRIES
Mar 5, 2004·The Lancet Infectious Diseases·D BogaertP W M Hermans
Jun 9, 2004·Journal of Clinical Microbiology·H-C SlotvedF Espersen
Feb 11, 2005·The Pediatric Infectious Disease Journal·Karen L SleemanDerrick W Crook
Jun 18, 2005·The Journal of Infectious Diseases·Julia LeimkugelGerd Pluschke
Jun 29, 2006·Advances in Experimental Medicine and Biology·Tim J Mitchell
Nov 28, 2006·Transactions of the Royal Society of Tropical Medicine and Hygiene·Richard E HollimanOhene Adjei
Feb 3, 2007·Journal of Clinical Microbiology·In Ho ParkMoon H Nahm
Nov 7, 2007·Drugs·Françoise Van BambekeWilly E Peetermans
Dec 29, 2007·The Pediatric Infectious Disease Journal·Osman AbdullahiJ Anthony G Scott
Jan 19, 2008·Journal of Medical Microbiology·Déa M CardozoMaria-Cristina C Brandileone
Jan 31, 2008·Future Microbiology·William P Hanage
Sep 15, 2009·Lancet·Katherine L O'BrienUNKNOWN Hib and Pneumococcal Global Burden of Disease Study Team
Jan 21, 2010·Scandinavian Journal of Infectious Diseases·Eric S DonkorEbenezer V Badoe
May 29, 2010·The Journal of Infectious Diseases·Juan J Calix, Moon H Nahm
Dec 1, 2011·Current Drug Abuse Reviews·Erica L Birkley, Gregory T Smith
Feb 8, 2013·Cell & Bioscience·Jingyin YueZhiyuan Shen
Sep 21, 2013·International Journal of General Medicine·Eric S DonkorEbenezer V Badoe
Oct 24, 2013·BMC Infectious Diseases·Nicholas T K D DayieHans-Christian Slotved
Citations
Apr 15, 2016·Clinical Microbiology Reviews·Lindsay KimBernard Beall
Nov 9, 2018·PloS One·Nicholas T K D DayieEric S Donkor
Nov 21, 2018·BMC Pediatrics·Archippe M BirindwaSusann Skovbjerg
Jan 10, 2019·Transactions of the Royal Society of Tropical Medicine and Hygiene·Holly C SmithJamie Rylance
Mar 19, 2019·Seminars in Ophthalmology·Bhavik PanchalTaraprasad Das
Jun 6, 2020·The Pan African Medical Journal·Pilar García-VelloCourage Kosi Setsoafia Saba
Mar 22, 2019·BioMed Research International·Nicholas Tkd DayieEric S Donkor
Dec 17, 2020·Microorganisms·Richael O MillsSven Hammerschmidt
Apr 16, 2021·Expert Review of Vaccines·Lassané KaboréAlain Gervaix