Epidemiology of pneumococcal carriage in children under five years of age in Accra, Ghana

Infectious Diseases
Richael Odarkor MillsEric S Donkor

Abstract

Although the majority of pneumococcal infections occur in the developing world, pneumococcal epidemiology is poorly understood in these settings. The aim of the study was to investigate the epidemiology of pneumococcal carriage among children younger than 5 years at a paediatric healthcare centre in Ghana. Four-hundred and twenty-three children were randomly sampled and nasopharyngeal specimens were collected from them. The specimens were cultured for Streptococcus pneumoniae, and the isolates were subjected to antibiotic susceptibility testing and serotyping by latex agglutination. Epidemiological data on demographic and clinical features of the study subjects were collected. The prevalence of pneumococcal carriage was 48.9% (207/422), with age groups 43-48 months having the highest carriage prevalence. In the multivariate analysis, pneumococcal carriage was significantly associated with runny nose (odds ratio = 1.9, p = 0.003) and day-care attendance (odds ratio = 1.5, p = 0.04). No pneumococcal resistance was observed for ceftriaxone, while the prevalence of resistance to the other antibiotics tested was: cotrimoxazole 100%, ampicillin 88%, tetracycline 78%, penicillin 63% and erythromycin 24%. Fourteen different pneumococca...Continue Reading

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Citations

Jan 10, 2019·Transactions of the Royal Society of Tropical Medicine and Hygiene·Holly C SmithJamie Rylance
Mar 19, 2019·Seminars in Ophthalmology·Bhavik PanchalTaraprasad Das
Jun 6, 2020·The Pan African Medical Journal·Pilar García-VelloCourage Kosi Setsoafia Saba

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