Epidemiology of Serotype 1 Invasive Pneumococcal Disease, South Africa, 2003-2013

Emerging Infectious Diseases
Claire von MollendorfGroup for Enteric, Respiratory, and Meningeal Disease Surveillance in South Africa (GERMS-SA)

Abstract

In South Africa, 7-valent pneumococcal conjugate vaccine (PCV) was introduced in April 2009 and replaced with 13-valent PCV in April 2011. We describe the epidemiology of serotype 1 Streptococcus pneumoniae disease during the pre- and post-PCV eras (2003-2013). Using laboratory-based invasive pneumococcal disease (IPD) surveillance, we calculated annual incidences, identified IPD clusters, and determined serotype 1-associated factors. Of 46,483 IPD cases, 4,544 (10%) were caused by serotype 1. Two clusters of serotype 1 infection were detected during 2003-2004 and 2008-2012, but incidence decreased after 2011. Among children <5 years of age, those who had non-serotype 1 IPD had shorter hospital stays, fewer cases of penicillin-nonsusceptible disease, and lower HIV prevalence and in-hospital death rates than did those with serotype 1 IPD; similar factors were noted for older patients. Serotype 1 IPD had distinctive clinical features in South Africa, and annual incidences fluctuated, with decreases noted after the introduction of PCV13.

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Citations

Nov 9, 2016·BMC Infectious Diseases·Chrispin ChaguzaUNKNOWN PAGe Consortium
Mar 11, 2016·Journal of Clinical Microbiology·Mignon du PlessisAnne von Gottberg
May 10, 2018·The Pediatric Infectious Disease Journal·Krishnee MoodleyAnne von Gottberg
Sep 11, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Papa M FayeJennifer L Farrar
Mar 19, 2019·The Pediatric Infectious Disease Journal·Krishnee MoodleyAnne von Gottberg

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Methods Mentioned

BETA
PCR

Software Mentioned

SaTScan
Stata
ArcGIS

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