Epidemiology of staphylococcal scalded skin syndrome in U.S. children

The British Journal of Dermatology
A StaimanJ I Silverberg

Abstract

Staphylococcal scalded skin syndrome (SSSS) is a blistering dermatosis caused by exfoliative toxins released from Staphylococcus aureus. To describe the incidence, costs, length of stay (LOS), comorbidities and mortality of SSSS in U.S. children. The Nationwide Inpatient Sample 2008-2012 was analysed, including a 20% sample of U.S. hospitalizations and 589 cases of SSSS. The mean annual incidence of SSSS was 7·67 (range 1·83-11·88) per million U.S. children, with 45·1 cases per million U.S. infants age < 2 years. In multivariable logistic regression models, SSSS was significantly associated with the following (shown as adjusted odds ratio and 95% confidence interval): female sex (1·12, 1·00-1·25), age (2-5 years: 13·31, 11·82-14·99; 6-10 years: 2·93, 2·35-3·66; 11-17 years: 0·44, 0·31-0·63); race/ethnicity (black: 0·69, 0·58-0·84) and season (winter: 2·04, 1·66-2·50; summer: 3·47, 2·86-4·22; autumn: 3·04, 2·49-3·70), with increasing odds over time (2010-2011: 2·28, 2·07-2·51; 2012: 2·98, 2·69-3·30). The geometric mean (95% confidence interval) LOS and cost of hospitalization for patients with vs. without SSSS were 3·2 (3·0-3·4) vs. 2·4 (2·4-2·5) days and $4624·0 ($4250-$5030) vs. $1872 ($1782·7-$1965). Crude inpatient mortality...Continue Reading

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Citations

Feb 1, 2019·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Hagen Ott
Oct 7, 2019·Clinical and Experimental Dermatology·D R MazoriS A Glick
Nov 15, 2019·The Pediatric Infectious Disease Journal·Kristina G HulténSheldon L Kaplan
May 13, 2020·Oxford Medical Case Reports·Matthew G DaveyMary E Laing
Apr 30, 2019·Advanced Emergency Nursing Journal·Kathleen S Jordan
Jul 1, 2020·Journal of Paediatrics and Child Health·Akihiro IguchiKatsuhiko Kitazawa
Feb 23, 2021·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Hannah C NeubauerSowdhamini S Wallace

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