Abstract
Because of co-morbidity, older persons are often exposed to use of an excessive number of drugs, which per se implies also use of inappropriate drugs or of potentially interacting drugs ('suboptimal prescribing'). Time trends of suboptimal prescribing in older, community dwellers have been poorly investigated, particularly in Italy. To evaluate the time-course modification of suboptimal prescribing in older, community dwellers. We conducted a study on an Italian cohort of older (aged>or=65 years), community dwellers for whom data were collected in a two-wave (1995 and 1999), population-based survey. Suboptimal prescribing was defined as occurrence of polypharmacy (>or=5 medications), prescription of inappropriate medications (according to 1991 Beers' criteria) and prescription of potentially interacting drugs (as identified by the Micromedex Drug-Reax system). All outcome variables were modelled as continuous and dichotomous. In 568 participants (59.9% women, mean+/-standard error age 72.7+/-0.2 years), polypharmacy and potentially interacting drugs were more prevalent in 1999 than in 1995, while prevalence of inappropriate drugs was lower in 1999. The proportion of participants receiving polypharmacy was nearly 3-fold greater ...Continue Reading
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