Epidemiology of viral infections and evaluation of the potential benefit of OM-85 BV on the virologic status of children attending day-care centers

Respiration; International Review of Thoracic Diseases
M AymardJ Gillet


Viral investigations were performed during 4 winter seasons (88/89, 89/90, 92/93, 93/94) in children attending day-care centers (DCCs) in the Rhône Département in eastern France. Over the total observation period of 4 winter seasons, 780 children were screened with a nasal swab for the presence of viruses. Of those, 230 (29.5%) had a positive viral culture. The viruses identified were respiratory syncytial virus (RSV), influenza A and B virus, parainfluenza virus, coronavirus, rhinovirus, adenovirus and enterovirus. During that time, 83 epidemic events in 47 DCC were recorded. A particular virus was judged to be causally related to an epidemic if the identical virus was isolated in > or = 3 children during the same outbreak of respiratory diseases. Thus, in 51 cases (61.4%) of all epidemics, the following viruses were responsible for an epidemic: RSV (n = 23), coronavirus (n = 10) (only during the season of 1993-1994), influenza A virus (n = 6), rhinovirus (n = 4), enterovirus (n = 4), adenovirus (n = 3) and parainfluenza virus (n = 1). Except for the somewhat surprising accumulation of coronavirus epidemics during the winter of 1993-1994, there were only minor seasonal variations from one year to another. As expected, RSV acco...Continue Reading


Oct 12, 2000·The Journal of Infection·M R KimG M Lee
Apr 3, 2003·The Pediatric Infectious Disease Journal·Lone Graff StensballeEric A Simoes
Feb 5, 2003·Pediatric Pulmonology·Leda Solano de Freitas SouzaEurico Arruda
Oct 21, 2006·The Cochrane Database of Systematic Reviews·B E Del-Rio-NavarroJ J L Sienra-Monge

Related Concepts

OM-85 BV
Immunologic Adjuvants
Cell Extracts
Day Care Centers for Children
Disease Outbreaks
Seasonal Variation
Virus Diseases

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