Epidermal differentiation in normal and growth-retarded infants: studies in two animal models and in human babies

The British Journal of Dermatology
A B Lansdown

Abstract

The influence of prenatal growth retardation on epidermal growth and keratinization was studied in small-for-dates human babies, runt piglets and in rat fetuses subject to maternal protein deprivation. In the human babies and rat fetuses growth retardation was associated with reduced epidermal growth but normal patterns of differentiation were present. Thus, epidermal thickness was less and keratinizing zones narrower than seen in normal weight individuals. In the runt (small-for-dates) piglet, epidermal development differed from that seen in normal weight piglets of the same gestational age and from that seen in the human and rat. The epidermis was thicker with a negligible stratum granulosum and with the stratum corneum containing nucleated cells, a condition resembling 'parakeratosis'. This pattern was less often seen in normal weight piglets. Differences between the skins of the three speecies studied at a perinatal stage may be related to clear dissimilarities which exist in the tissues later. Parakeratosis as a transitory phase in the development of pig skin is probably related to a higher rate of epidermal keratinization in this species than occurs in either human babies or rat fetuses.

References

Oct 1, 1971·Journal of Ultrastructure Research·K A WierW L Epstein
May 1, 1972·The British Journal of Dermatology·R Marks
Oct 1, 1973·Developmental Medicine and Child Neurology·B Hutchinson-Smith
Jul 1, 1973·The British Journal of Dermatology·A B Lansdown
Dec 1, 1970·The Journal of Cell Biology·A G Matoltsy, M N Matoltsy
Jul 1, 1969·The British Journal of Dermatology·A S Breathnach, J Robins
Jun 1, 1966·Archives of Disease in Childhood·V Farr
Jan 1, 1964·Experimental Cell Research·W S BULLOUGH, E B LAURENCE
Aug 1, 1959·The British Journal of Dermatology·A JARRETTJ A HARDY

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Citations

Aug 25, 1999·Journal of the American Academy of Dermatology·P B ColditzI M Robertson
Jan 9, 2020·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Laura PolányiMiguel A Alejandre Alcazar
Dec 2, 2004·British Journal of Nursing : BJN·Alan B G Lansdown

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