Epidermal differentiation in the human external auditory meatus

The Laryngoscope
P P VennixF C Ramaekers

Abstract

The differentiation of epidermis in the various parts of the human ear canal was documented on the basis of cytokeratin (Ck) expression patterns. Immunohistochemistry was performed on cryostat sections of normal meatal skin using a comprehensive panel of monospecific Ck antibodies representing the main lines of epithelial differentiation. The epidermis of the cartilaginous part showed a Ck profile characteristic of normal skin type differentiation. The deep meatal skin, including the tympanic membrane, showed a peculiar type of differentiation: in addition to epidermal Cks, hyperproliferation-associated Cks 6, 16, and 17 were expressed in the suprabasal cells, while the simple epithelia cell marker Ck 19 was found in the basal cells. The presence of hyperproliferative Cks in the deep meatal skin could only partly be related to areas of proliferative activity. Keratinocytes, which express markers of hyperproliferation, are migratory. Therefore, their presence in the meatal skin is likely to be related to the peculiar pattern of keratinocyte migration, the purpose of which is to keep the meatus free from desquamation products.

References

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Citations

Nov 14, 1997·International Journal of Pediatric Otorhinolaryngology·L P SchousboeT Ledet
Dec 16, 1998·The Laryngoscope·J J MulderF C Ramaekers
Jan 25, 2013·ISRN Surgery·Shafik N WassefSamuel Barnett
Jan 1, 1997·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·L A van der VeldenW Kuijpers
Sep 21, 2006·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Michael WolfJona Kronenberg
Feb 9, 2007·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Mélanie SanjuanJacques Magnan
Oct 31, 2009·Biology Letters·Roshan K VijendravarmaTadeusz J Kawecki
Jan 12, 2017·Clinical and Experimental Otorhinolaryngology·Mahmood A HamedYutaka Tsutsumi
Apr 7, 2018·Journal of the Association for Research in Otolaryngology : JARO·Peder AabelMagnus von Unge

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