Epidermal Expression and Regulation of Interleukin-33 during Homeostasis and Inflammation: Strong Species Differences

The Journal of Investigative Dermatology
Olav SundnesDenis Khnykin

Abstract

IL-33 is a novel IL-1 family member with a putative role in inflammatory skin disorders and a complex biology. Therefore, recent conflicting data regarding its function in experimental models justify a close assessment of its tissue expression and regulation. Indeed, we report here that there are strong species differences in the expression and regulation of epidermal IL-33. In murine epidermis, IL-33 behaved similar to an alarmin, being constitutively expressed in keratinocyte nuclei and rapidly lost during acute inflammation. By contrast, human and porcine IL-33 were weakly expressed or absent in keratinocytes of noninflamed skin but induced during acute inflammation. To this end, we observed that expression of IL-33 in human keratinocytes but not murine keratinocytes was strongly induced by IFN-γ, and this upregulation completely depended on the presence of EGFR ligands. Accordingly, IFN-γ increased the expression of IL-33 in the basal layers of the epidermis in human ex vivo skin cultures only, despite good evidence of IFN-γ activity in cultures from both species. Together these findings demonstrate that a full understanding of IL-33 function in clinical settings must take species-specific differences into account.

References

May 15, 2001·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·T P SullivanP Mertz
Jun 24, 2003·The American Journal of Pathology·Espen S BaekkevoldJean-Philippe Girard
Oct 12, 2004·Experimental Cell Research·Lene Melsaether GrøvdalInger Helene Madshus
Aug 25, 2005·Human Molecular Genetics·Makiko ShimizuTaro Shirakawa
Dec 23, 2006·Proceedings of the National Academy of Sciences of the United States of America·Virginie CarriereJean-Philippe Girard
Apr 4, 2008·The New England Journal of Medicine·Thomas Bieber
Apr 9, 2008·Dermatologic Therapy·Gionata BuggianiTorello Lotti
Apr 11, 2009·Trends in Immunology·Guttorm HaraldsenAxel M Küchler
Oct 27, 2009·Nucleic Acids Research·Lewis Y GeerStephen H Bryant
Jan 1, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrew L RankinStefan Pflanz
Mar 2, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hideaki KouzakiHirohito Kita
Mar 9, 2011·Pflügers Archiv : European journal of physiology·Balázs I TóthTamás Bíró
Apr 27, 2011·Nature Reviews. Rheumatology·Gaby Palmer, Cem Gabay
Jun 16, 2011·European Journal of Immunology·Axel J HueberIain B McInnes
Jul 8, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shafaqat AliMichael Uwe Martin
Jan 5, 2012·The Journal of Biological Chemistry·Rahul KakkarRichard T Lee
Jan 27, 2012·The Journal of Investigative Dermatology·Terhi SavinkoHarri Alenius
Mar 1, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mélanie PicheryJean-Philippe Girard
Jun 8, 2012·The Journal of Investigative Dermatology·Jitlada MeephansanMamitaro Ohtsuki
Jan 18, 2013·Arthritis Research & Therapy·Praxedis MartinGaby Palmer
Feb 1, 2013·Experimental Dermatology·Jenny SeltmannMiriam Wittmann
Feb 1, 2013·Science Translational Medicine·Brian S KimDavid Artis
May 17, 2013·BMC Genomics·Harry D DawsonChristopher K Tuggle
Aug 7, 2013·Proceedings of the National Academy of Sciences of the United States of America·Yasutomo ImaiKiyofumi Yamanishi
Aug 16, 2013·The Journal of Clinical Investigation·Derek E ByersMichael J Holtzman
Aug 21, 2013·Immunity·Tamar McHedlidzeStefan Wirtz
Dec 11, 2013·The Journal of Experimental Medicine·Maryam SalimiGraham S Ogg
Apr 3, 2014·Developmental and Comparative Immunology·Nikolay V OgryzkoHeather L Wilson

❮ Previous
Next ❯

Citations

Jan 20, 2016·Nature Immunology·Nikolas T Martin, Michael U Martin
Jun 18, 2015·Immunity·Ari B MolofskyRichard M Locksley
Mar 13, 2016·Archives of Dermatological Research·Anna BalatoSerena Lembo
Jun 19, 2016·Arthritis Research & Therapy·Sara Khaleghparast AthariNatacha Bessis
Aug 16, 2016·Seminars in Cell & Developmental Biology·Neal L MillarElizabeth Brint
Oct 6, 2016·Mediators of Inflammation·Carl D RichardsFernando Botelho
Feb 4, 2016·Toxicologic Pathology·Tina Rubic-SchneiderMichael Kammüller
Dec 17, 2017·Immunological Reviews·Corinne Cayrol, Jean-Philippe Girard
Mar 3, 2018·Veterinary Dermatology·Ryota AsahinaSadatoshi Maeda
Aug 3, 2020·Veterinary Medicine and Science·Enrico GugliandoloRosalia Crupi
Apr 6, 2019·Frontiers in Immunology·Fernando AlvarezCiriaco A Piccirillo
Nov 19, 2019·Mediators of Inflammation·Serafinella Patrizia CannavòSebastiano Gangemi
Jul 11, 2018·Frontiers in Immunology·Manoussa FannyIsabelle Couillin
Aug 16, 2018·Nature Communications·Jared TraversMarc E Rothenberg
Feb 19, 2021·Frontiers in Immunology·Peter W WestSilvia Bulfone-Paus
Apr 17, 2020·Current Pharmaceutical Biotechnology·Grażyna JanikowskaTomasz Janikowski

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.