Epidermal grafting for leukoderma resulting from 1064-nm quality-switched neodymium-doped yttrium aluminium garnet laser toning.

International Wound Journal
Yen-Jen Wang, Chang-Cheng Chang

Abstract

Leukoderma secondary to Q-switched 1064-nm neodymium-doped yttrium aluminium garnet laser is usually refractory to treatment. The pathogenesis was cumulative phototoxic damage to melanocytes and eventually resulted in melanocytopenia. Wood's light or UV imaging can help observe early leukoderma before it becomes apparent clinically and determine the degree of melanocytopenia before conducting a biopsy. NB-UVB phototherapy and 308-nm excimer laser can potentially worsen the pre-existing melasma lesions and may not be effective if the lesions have already become melanocytopenic. Epidermal grafting can replenish the hypopigmented area with melanocytes without worsening melasma.

References

Jul 10, 2001·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·P E GrimesG Lask
Oct 22, 2010·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Taegyun KimSang Ho Oh

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