PMID: 6975292Dec 1, 1981Paper

Epidermal growth factor and proliferation of odontogenic cells in culture

Journal of Dental Research
N E Steidler, P C Reade

Abstract

The proliferation of bovine odontogenic epithelial (OE) and mesenchymal (OM) cells cultured in the presence of varying concentrations of epidermal growth factor (EGF) was examined. After a delay of two to three d, EGF-supplemented cultures contained significantly more cells than did controls. This effect was dose-dependent, was maximal at 10-9 g EGF/ml for OE and 10-8 g EGF/ml for OM, and was dependent on the presence of serum in the culture medium. The results suggest the possibility that EGF may play a role in the control of odontogenic cell proliferation in vivo.

References

Feb 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·S E Hutchings, G H Sato
Dec 1, 1977·The Journal of Clinical Endocrinology and Metabolism·R H Starkey, D N Orth
Jun 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·M Das, C F Fox
Jan 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·K J Lembach
Oct 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·M D Hollenberg, P Cuatrecasas
Sep 1, 1974·Endocrinology·R L ByynyE S Doyne
Feb 1, 1973·American Journal of Obstetrics and Gynecology·I G Ances
Jan 1, 1980·Archives of Oral Biology·S S Prime, P C Reade

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