Epidermal growth factor as a potential prognostic and predictive biomarker of response to platinum-based chemotherapy.

PloS One
Margot GeensKristien J Ledeganck

Abstract

In this study, we investigated serum epidermal growth factor (EGF) in an oncological population of head- and neck and pulmonary neoplasms and whether serum EGF could serve as a prognostic marker of survival and as a predictive marker for treatment response to platinum-based chemotherapy. A total of 59 oncological patients and a control group of age- and sex-matched healthy volunteers were included in this study. Pre-treatment serum EGF from both groups was determined. Patient's and tumour characteristics and mortality were recorded during a 5-year follow up period. Baseline serum EGF significantly differed between the oncological patients and the healthy volunteers (p<0.001). Serum EGF was associated with lymph node metastasis (p = 0.004) but not with sex (p = 0.753), age (p = 1.00), TNM stage (p = 0.191) or tumour size (p = 0.077). Neither serum EGF (p = 0.81) nor age (p = 0.55) showed an effect on the patient's survival. Tumour location was significantly associated with overall 5-year survival (p = 0.003). The predictive capacity of serum EGF of response to chemotherapy was limited (AUC = 0.606), a sensitivity of 80% and a specificity of 56% was observed resulting in a likelihood ratio of a positive and negative test equal to...Continue Reading

References

Jun 13, 1998·Journal of the National Cancer Institute·J Rubin GrandisD J Tweardy
Feb 4, 2005·Langenbeck's Archives of Surgery·Aleksander KonturekWojciech Cichoń
Oct 21, 2005·Chest·Eija-Riitta SalomaaKari Liippo
Dec 17, 2005·Cancer Biology & Therapy·Tania Crombet RamosAgustín Lage Dávila
Dec 8, 2006·Respiratory Medicine·Heidi B RolkeFrode Gallefoss
Aug 28, 2010·Cancer Prevention Research·Mark W Lingen
Mar 19, 2011·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·H MehannaC Nutting
Mar 26, 2011·Applied Immunohistochemistry & Molecular Morphology : AIMM·Vanessa Fátima BernardesMaria Cássia Ferreira Aguiar
Nov 18, 2011·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Nicholas HarperRobert C G Martin
Nov 9, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Annelies A van AngelenRené J M Bindels
Dec 4, 2012·Seminars in Thoracic and Cardiovascular Surgery·Adrian T BilleterVictor H van Berkel
Mar 5, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Gearoid M McMahon, Sushrut S Waikar
Mar 5, 2013·PloS One·Kristien J LedeganckBenedicte Y De Winter
Sep 12, 2013·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Alexander GröbeMarco Blessmann
Feb 12, 2014·Seminars in Cell & Developmental Biology·Fenghua Zeng, Raymond C Harris
May 21, 2015·PloS One·Sonia Blanco-PrietoMaría Páez de la Cadena
Oct 6, 2015·Biochemical and Biophysical Research Communications·Abhishek GuptaSharmistha Dey
Jan 26, 2016·Journal of Cellular Biochemistry·Ajay BansalKenneth Wang
Mar 28, 2017·Biochemical and Biophysical Research Communications·Jing ChengGuangyong Zheng
Feb 6, 2018·Advances in Therapy·Andrés Coca-PelazAlfio Ferlito
Jan 25, 2019·PloS One·Sarang MeyboschKristien J Ledeganck
Sep 21, 2019·Scientific Reports·Malte KriegsAdrian Münscher
Jul 17, 2020·Frontiers in Oncology·Heleen KoningsKristien J Ledeganck

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