Epidermal growth factor deficiency associated with diabetes mellitus.

Proceedings of the National Academy of Sciences of the United States of America
S KasayamaT Oka

Abstract

The production of epidermal growth factor (EGF) in the submandibular gland and its circulating level were studied in diabetic mice. In genetically diabetic (C57BL/KsJ db/db) mice, EGF concentrations in the submandibular gland and plasma were reduced to 13% and 30% of the control levels, respectively. In streptozotocin-treated diabetic mice, they were reduced to 18% and 20% of controls, respectively, 5 weeks after the drug injection. Furthermore, levels of submandibular prepro-EGF mRNA in these diabetic mice were decreased almost in parallel with the glandular EGF concentrations, while there was no change in the levels of submandibular beta-actin mRNA and kidney prepro-EGF mRNA. In addition, histological examination of the submandibular glands indicated that the size of the granular convoluted tubules, which produce EGF, was substantially reduced in the diabetic mice. Insulin administration to streptozotocin-treated mice almost completely reversed the decrease in EGF content in the submandibular gland, substantially elevated the level of the glandular prepro-EGF mRNA and plasma EGF concentration, and increased the size of the granular convoluted tubules in the gland. These results indicate that EGF deficiency occurs in diabetes ...Continue Reading

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Citations

May 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·G Serrero, D Mills
Apr 15, 2014·Mediators of Inflammation·Marta GrecoElio Gulletta
Jan 31, 2006·Journal of Physiology and Biochemistry·F N NogueiraJ Nicolau
Aug 8, 2009·International Journal of Experimental Pathology·Maija I MednieksArthur R Hand
Dec 7, 2007·Journal of Cellular and Molecular Medicine·H Y LeeS H Ryu
May 12, 2010·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Monica PirasMarco Piludu
Jul 2, 2011·Oral Diseases·M IsolaM Cossu
Aug 28, 2010·Oral Diseases·M IsolaM S Lantini
Aug 29, 2012·Diabetes/metabolism Research and Reviews·S Gezginci-OktayogluS Bolkent
Aug 25, 2010·Archives of Oral Biology·Kazuhiko OkamuraJun Yamazaki
Jul 1, 1993·Diabetes Research and Clinical Practice·J ThulesenS S Poulsen
May 7, 2020·Frontiers in Physiology·Meng ZhaoKatrin J Svensson

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