Epidermal growth factor gene (EGF) polymorphism and risk of melanocytic neoplasia

The Journal of Investigative Dermatology
Michael R JamesDavid L Duffy

Abstract

A common single nucleotide polymorphism (SNP) in the 5' untranslated region (5'UTR) of the epidermal growth factor (EGF) gene modulates the level of transcription of this gene and hence is associated with serum levels of EGF. This variant may be associated with melanoma risk, but conflicting findings have been reported. An Australian melanoma case-control sample was typed for the EGF+61A>G transversion (rs4444903). The sample comprised 753 melanoma cases from 738 families stratified by family history of melanoma and 2387 controls from 645 unselected twin families. Ancestry of the cases and controls was recorded, and the twins had undergone skin examination to assess total body nevus count, degree of freckling and pigmentation phenotype. SNP genotyping was carried out via primer extension followed by matrix-assisted laser desorption time of flight (MALDI-TOF) mass spectroscopy. The EGF+61 SNP was not found to be significantly associated with melanoma status or with development of nevi or freckles. Among melanoma cases, however, G homozygotes had thicker tumors (p=0.05), in keeping with two previous studies. The EGF polymorphism does not appear to predispose to melanoma or nevus development, but its significant association with t...Continue Reading

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Citations

Sep 25, 2008·Cancer Causes & Control : CCC·Hongmei NanJiali Han
Feb 24, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·S KangH-P Lee
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Sep 6, 2015·Pigment Cell & Melanoma Research·Matjaz VogelsangTomas Kirchhoff
Dec 16, 2005·The Journal of Investigative Dermatology·Hensin Tsao
Dec 16, 2005·The Journal of Investigative Dermatology·Michael R JamesDavid L Duffy
Sep 18, 2004·The Journal of Investigative Dermatology·W Martin Howell
May 13, 2006·The Journal of Investigative Dermatology·Ichiro OkamotoHubert Pehamberger
Dec 16, 2006·The Journal of Investigative Dermatology·Hind BerrahmouneSophie Visvikis-Siest
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