Epidermal growth factor in the submandibular glands of inbred mice

The American Journal of Anatomy
M Tom-Moy, T Barka

Abstract

Epidermal growth factor (EGF), and androgen-dependent polypeptide, occurs in high concentration in male mouse submandibular gland. Glands of adult male and female mice of six inbred strains (129/J, C57BL/6J, C58/J, SWR/J, RF/J, A/J) were assayed for EGF by radioimmunoassay. In all strains, the glands of males contained 30 to 500-fold more EGF than those of females. Furthermore, significant differences in EGF content were found among the various strains in both sexes, the highest amount of EGF was present in RF/J and the lowest in C57BL/6J, with a ratio of three in the males and four in the females of the two strains, respectively. Factors that effect EGF levels were analyzed further, using these two strains. EGF was measurable in the glands of mice of both strains at 21 days of age and increased rapidly thereafter, up to 14 weeks of age. Throughout postnatal development, the level of EGF was greater in the glands of RF/J mice than in those of the C57BL/6J animals. Thirty days after castration, the EGF levels were reduced by about 98% in both strains, but the strain difference was not abolished. Testosterone implants (1 mg in Silastic tube) in castrated mice induced EGF levels six- to ten-fold compared to castrates. Even in indu...Continue Reading

References

Mar 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·C M WilsonJ D Wilson
Aug 1, 1979·Developmental Biology·R A MurphyM Papastavros
Jan 17, 1978·Cell and Tissue Research·T BarkaH vad der Noen
Nov 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·C M WilsonB A Taylor
Sep 1, 1977·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·E Gresik, T Barka
Jan 1, 1979·Annual Review of Biochemistry·G Carpenter, S Cohen
May 18, 1979·Cell and Tissue Research·R Srinivasan, W W Chang
Apr 1, 1975·Journal of Cellular Physiology·K PaigenR E Ganschow
Sep 1, 1974·Endocrinology·R L ByynyE S Doyne
Jul 1, 1972·The Journal of Clinical Investigation·J L Goldstein, J D Wilson
Apr 1, 1973·Endocrinology·A BartkeB V Caldwell
Jan 1, 1969·International Review of Cytology·E R Weibel
May 1, 1972·Endocrinology·R L ByynyS Cohen
Jan 1, 1966·Endocrinology·P J Dziuk, B Cook
Oct 1, 1967·Proceedings of the Society for Experimental Biology and Medicine·F HiltonM Dickie
May 1, 1958·Proceedings of the Society for Experimental Biology and Medicine·C A SCHNEYER

❮ Previous
Next ❯

Citations

Jan 1, 1994·Microscopy Research and Technique·E W Gresik
Jan 1, 1991·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·M KashimataN Minami
Oct 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·A W BurgessE C Nice
Jan 1, 1984·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·J R HullyM R Alison
Mar 4, 2003·Pesquisa odontológica brasileira = Brazilian oral research·Rumio Taga, Luiz Carlos Pardini

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.