Epidermal growth factor induces the expression of its receptor gene in human gastric carcinoma cell line TMK-1

Japanese Journal of Cancer Research : Gann
K YoshidaE Tahara

Abstract

To ascertain the possible autocrine pathway in the growth promotion of gastric carcinomas, a study was made on the effects of exogenous human epidermal growth factor (hEGF) on the expression of mRNA for EGF, transforming growth factor-a (TGF-a), EGF receptor, FOS and MYC genes by TMK-1 cells. Exogenous hEGF increased FOS and MYC mRNA levels 30 min and 1 h after the treatment, respectively. TMK-1 cells accumulated the mRNA for EGF receptor about 7- to 8-fold by 3 h after treatment. Expressions of mRNA for EGF and TGF-a genes were detected, but the amounts of the mRNA of these genes in TMK-1 cells were not altered after the treatment.

References

Feb 15, 1988·International Journal of Cancer. Journal International Du Cancer·W YasuiE Tahara
Dec 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·A J ClarkI Pastan

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Citations

Jan 1, 1990·Journal of Cancer Research and Clinical Oncology·E Tahara
Jan 1, 1990·Experimental Pathology·K YoshidaE Tahara
Jan 1, 1994·Baillière's Clinical Endocrinology and Metabolism·G S Baldwin, R H Whitehead
May 15, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Y D JungL M Ellis
Aug 13, 1998·Pathology International·S YamamotoE Tahara
Jan 1, 1993·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·H P VollmersH K Müller-Hermelink
Jan 1, 1990·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·M ItoE Tahara
Jan 1, 1998·Japanese Journal of Cancer Research : Gann·Y KudoE Tahara
Aug 1, 1993·Japanese Journal of Cancer Research : Gann·Y KitadaiE Tahara
Feb 4, 1998·The British Journal of Surgery·H AllgayerF W Schildberg
Jul 23, 2014·Oncology Reports·Yutaka NaitoWataru Yasui
Jan 15, 1990·International Journal of Cancer. Journal International Du Cancer·K YoshidaE Tahara
Jan 20, 1999·European Journal of Clinical Investigation·U WulbrandH Fehmann
Dec 30, 1992·Biochemical and Biophysical Research Communications·Y KitadaiE Tahara

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