PMID: 7540616Jul 1, 1995Paper

Epidermal growth factor promotes a neural phenotype in thymic epithelial cells and enhances neuropoietic cytokine expression

The Journal of Cell Biology
I ScrepantiA Gulino

Abstract

Neural crest-derived cells populate the thymus, and their coexistence with epithelial cells is required for proper organ development and T cell education function. We show here that epidermal growth factor (EGF), a major epithelial cell growth-enhancing agent, has a morphogenetic action to promote the expression of a neuronal phenotype (e.g., neurofilament expression) in cultured thymic epithelial cells that are characterized by a cytokeratin-positive epithelial cell background. The proliferation of such neurodifferentiated cells is also enhanced by EGF. Furthermore, the growth factor enhances cells that express the genes encoding the preprotachykinin A-generated neuropeptides and bipotential neuropoietic and lymphopoietic cytokines ciliary neurotrophic factor and interleukin-6. These cytokines also enhance the neuronal phenotype of thymic epithelial cells. Therefore, EGF appears to be a composite autocrine/paracrine neuromodulator in thymic stroma. This suggests that EGF may regulate thymus-dependent immune functions by promoting neuronal gene expression in neural crest-derived cells.

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Citations

Jun 5, 2002·Journal of Neuroimmunology·Giuseppe ScalabrinoP Magni
Apr 17, 2002·Expert Opinion on Biological Therapy·Bela Bodey
Aug 21, 2002·The Journal of Cell Biology·Rita GalloAlberto Gulino
Nov 25, 2003·Microscopy Research and Technique·Olivia García-SuárezGiovanni Germanà
Feb 12, 2008·Journal of Neuroimmunology·Ivan PilipovićGordana Leposavić
Nov 25, 2003·Microscopy Research and Technique·Renata Brelińska
Mar 28, 2001·Annals of the New York Academy of Sciences·M MaroderI Screpanti
Oct 16, 2010·Journal of Proteome Research·Rukhsana SultanaD Allan Butterfield

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