PMID: 6982423Nov 11, 1982Paper

Epidermal growth factor rapidly stimulates prolactin gene transcription

Nature
G H MurdochM G Rosenfeld

Abstract

Epidermal growth factor (EGF) was originally characterized as a growth factor for various cell types1,2 and was subsequently shown to affect a number of cellular and molecular processes3,4, of which many might be considered as a part of the pleiotropic growth response (enhanced uptake of glucose, uridine and amino acids and stimulated synthesis of protein, RNA and DNA). Very early responses to EGF, such as increased sodium fluxes5 and stimulation of tyrosine phosphorylation6, have been proposed to mediate some or all of EGF's effects. In a number of tissues, EGF has been shown to increase the synthesis of specific proteins7-10. We have investigated the effects of EGF on prolactin synthesis in the GH4 rat pituitary cell line to gain further insight into the mechanism of EGF's actions on cellular functions. Addition of EGF to GH4 cells results in a three- to sixfold stimulation of prolactin synthesis, as well as a partial inhibition of cell growth7,8. In this report, we demonstrate that the increased prolactin synthesis appears to be the result of a rapid stimulation of prolactin gene transcription by EGF. It is tempting to speculate that very early transcription by EGF. It is tempting to speculate that very early transcriptional...Continue Reading

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Citations

Jan 1, 1985·Cell and Tissue Research·K A NaveM Schachner
May 1, 1984·Developmental Biology·E D Adamson, J Meek
Feb 16, 1991·Biochimica Et Biophysica Acta·H T ChenW C Chang
Apr 1, 1988·Molecular and Cellular Endocrinology·M Nilsen-HamiltonR T Hamilton
Dec 1, 1988·Molecular and Cellular Endocrinology·P A CattiniM Nachtigal
Feb 12, 1990·Molecular and Cellular Endocrinology·A E JacksonC Bancroft
Mar 1, 1994·Molecular and Cellular Endocrinology·C Ying, J Gorski
Jan 1, 1990·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·D CondorelliA M Giuffrida-Stella
May 24, 2003·Frontiers in Neuroendocrinology·Andy Levy, Stafford Lightman
Jul 20, 1999·Molecular and Cellular Endocrinology·E SeuntjensC Denef
Aug 4, 1999·Molecular and Cellular Endocrinology·K K JacobF M Stanley
Nov 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·J HapgoodJ Schlessinger
Nov 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·S HashimotoG Schütz
Nov 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·A C LarnerJ E Darnell
Dec 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·P K ElderM J Getz
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·D LevyJ E Darnell
Nov 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·X Y FuJ E Darnell
Aug 30, 1994·Proceedings of the National Academy of Sciences of the United States of America·C A Pickett, A Gutierrez-Hartmann
Sep 15, 2011·The Journal of Biological Chemistry·Maik DahlhoffMarlon R Schneider
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Jun 10, 1988·Nucleic Acids Research·Y JinnoI Pastan
Jul 4, 2012·International Journal of Endocrinology·Sana SiddiquiStuart Maudsley
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Nov 23, 2011·The Journal of Clinical Investigation·Hidenori FukuokaShlomo Melmed
Sep 16, 2011·Endocrine-related Cancer·Odelia CooperShlomo Melmed

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