Epidermal growth factor receptor as a target to improve treatment of lung cancer

Clinical Lung Cancer
Nicolaus H AndratschkeLuka Milas

Abstract

Despite considerable efforts to reduce tobacco use, lung cancer remains the most common cancer in both men and women. Recent advances in radiation therapy and chemotherapy for lung cancer have yielded encouraging results, but survival in patients with locally advanced non-small-cell lung cancer (NSCLC) remains poor. As more and more molecular changes and their importance in malignant tissues continue to be characterized, approaches to target those aberrant pathways are being actively explored. The epidermal growth factor receptor (EGFR) is commonly overexpressed in NSCLC, particularly squamous cell carcinoma, and has been implicated in the development and progression of this disease, although a clear correlation with prognosis has not been established. Several different strategies have been developed to target and block the EGFR and its downstream effects, and some of them have been intensively studied in preclinical and clinical studies as a single-agent approach or in combination with radiation therapy or chemotherapy. In this article, we review the role of EGFR in lung cancer, as well as preclinical and clinical data on strategies to interfere with EGFR signaling alone or in combination with chemotherapy, radiation, or both.

References

Jan 1, 1979·Annual Review of Biochemistry·G Carpenter, S Cohen
Feb 20, 1992·The New England Journal of Medicine·C Schaake-KoningA Nijs
May 1, 1987·British Journal of Cancer·D VealeA L Harris
Jan 1, 1988·Annual Review of Biochemistry·Y Yarden, A Ullrich
Apr 1, 1986·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·I R Radford
Jul 1, 1985·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·I R Radford
Aug 1, 1984·The Journal of Clinical Investigation·F J Hendler, B W Ozanne
Nov 1, 1995·International Journal of Radiation Oncology, Biology, Physics·W C DeweyR E Meyn
Jul 1, 1995·Critical Reviews in Oncology/hematology·D S SalomonN Normanno
Jan 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G FontaniniG Bevilacqua
Jul 1, 1994·International Journal of Radiation Oncology, Biology, Physics·R K Schmidt-UllrichD McWilliams
Aug 30, 1994·International Journal of Radiation Oncology, Biology, Physics·R WollmanZ Fuks
Jan 21, 1993·International Journal of Cancer. Journal International Du Cancer·O EngebraatenO D Laerum
Apr 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B JeremicS Milisavljevic
Jul 1, 1996·The Journal of Pathology·S B FoxA L Harris
Oct 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J T PriceN E Haites
Nov 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S FujinoA Mori
Aug 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·U PastorinoF Rilke
May 1, 1998·American Journal of Respiratory and Critical Care Medicine·T M GreatensD E Niewoehner
Sep 2, 1998·Proceedings of the National Academy of Sciences of the United States of America·D M O'RourkeM I Greene

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