Epidermal growth factor receptor expression and activation in neuroendocrine tumours

Journal of Neuroendocrinology
T ShahM Caplin

Abstract

Epidermal growth factor receptor (EGFR) is expressed in many cancers and is associated with poor prognosis. EGFR activation pathways have been well characterised using tumour cell lines and are known to involve EGFR activation through autophosphorylation. Phosphorylation of downstream signalling molecules, such as ERK1/2 (extra-cellular regulated kinase 1 and 2) and PKB/Akt (protein kinase B), leads to enhanced tumour cell survival and proliferation. Although EGFR expression has been determined in neuroendocrine tumour tissue, its activation and subsequent effects on the downstream signalling molecules, ERK1/2 and Akt, have not been studied. We therefore planned to determine the role of EGFR in neuroendocrine tumours (NETs) by determining its pattern of expression and activation, and the subsequent activation of downstream signalling molecules ERK1/2 and Akt. Paraffin-embedded tumour tissue was available from 98 patients with NETs (39 foregut, 42 midgut, four hindgut, five paragangliomas, and four of unknown origin). Immunohistochemical evaluation was performed for the expression of EGFR, p-EGFR, p-Akt, and p-ERK1/2. Ninety-six percent of tumour samples were positive for EGFR expression; 63% were positive for activated EGFR; 76...Continue Reading

References

Sep 1, 1992·Neuron·J Schlessinger, A Ullrich
Oct 1, 1992·Trends in Biochemical Sciences·M J Pazin, L T Williams
Apr 20, 1990·Cell·A Ullrich, J Schlessinger
Jan 1, 1994·Growth Factors·L C GroenenA W Burgess
Sep 1, 1996·The Annals of Thoracic Surgery·V W RuschE S Venkatraman
Aug 1, 1996·Cytokine & Growth Factor Reviews·V RuschE Dmitrovsky
Feb 15, 1997·Cancer·I M Modlin, A Sandor
Nov 1, 2000·Cell·J Schlessinger
Mar 17, 2001·Nature Reviews. Molecular Cell Biology·Y Yarden, M X Sliwkowski
Mar 21, 2002·Expert Review of Molecular Diagnostics·G RindiA Scarpa
Jul 23, 2004·The New England Journal of Medicine·David CunninghamEric Van Cutsem
Oct 12, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Benjamin FriedmannDaniel Hochhauser
Feb 19, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael P DiGiovannaAnn D Thor
May 28, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A P Dei Tos, I Ellis
Jun 29, 2005·Cellular Signalling·Amar B Singh, Raymond C Harris
Jul 15, 2005·The New England Journal of Medicine·Judith A GilbertMatthew M Ames

❮ Previous
Next ❯

Citations

Sep 27, 2006·Pituitary·Eva Hofsli
Nov 10, 2009·Targeted Oncology·Jaume Capdevila, Ramon Salazar
Aug 15, 2012·Targeted Oncology·S CingarliniG Tortora
Dec 19, 2009·Molecular & Cellular Proteomics : MCP·Rajaventhan SrirajaskanthanNicholas J Beaumont
Jul 11, 2013·Journal of the National Cancer Institute·Jianliang ZhangSteven N Hochwald
Apr 14, 2012·Endocrine-related Cancer·Kathrin ZitzmannChristoph J Auernhammer
Aug 21, 2012·Cancer Management and Research·Kein-Leong Yim
Oct 9, 2013·International Journal of Oncology·Kathrin ZitzmannChristoph J Auernhammer
Nov 7, 2007·Wiener klinische Wochenschrift·Christoph J Auernhammer, Burkhard Göke
Apr 25, 2009·Expert Opinion on Investigational Drugs·Dan Granberg
Jan 23, 2016·Frontiers in Endocrinology·Helen Louise Robbins, Angela Hague
Nov 26, 2010·Endocrinology and Metabolism Clinics of North America·Barbara Zarebczan, Herbert Chen
Mar 3, 2009·Critical Reviews in Oncology/hematology·Gabriele CapursoGianfranco Delle Fave
Mar 21, 2009·Alimentary Pharmacology & Therapeutics·R SrirajaskanthanM E Caplin
May 25, 2011·European Journal of Clinical Investigation·Janet L Cunningham, Eva T Janson
May 15, 2015·Journal of the National Cancer Institute·Rony A FrançoisMaria Zajac-Kaye
Jan 27, 2015·Journal of Hepato-biliary-pancreatic Sciences·Gabriele CapursoGianfranco Delle Fave
May 8, 2015·Endocrine-related Cancer·Andrea WeckmanKalman Kovacs
Aug 3, 2013·Molecular and Cellular Endocrinology·Alan Meeker, Christopher Heaphy
Dec 12, 2012·Biochimica Et Biophysica Acta·Alessia Di FlorioRobert T Jensen
Oct 19, 2016·Nature Reviews. Clinical Oncology·Mark KiddKjell Öberg
Dec 7, 2010·Cancer Treatment Reviews·Nicola FazioFilippo de Braud
May 5, 2017·Journal of Molecular Endocrinology·Patricia CarrascoOriol Casanovas
Nov 11, 2017·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·P GajateE Grande
May 18, 2018·Endocrine-related Cancer·Federica GrilloUNKNOWN NIKE Group
Dec 14, 2017·Endocrine-related Cancer·Anela BlaževićWouter W de Herder
Dec 12, 2018·Pancreas·Bhavina D O Batukbhai, Ana De Jesus-Acosta
Jan 8, 2019·Endocrine-related Cancer·Aura D Herrera-MartínezRichard A Feelders
Jun 28, 2019·Current Pharmaceutical Design·Chang GaoJing Liu
Sep 17, 2020·Reviews in Endocrine & Metabolic Disorders·Giovanni VitaleMaria Chiara Zatelli
Sep 15, 2012·Experimental and Therapeutic Medicine·Greta AlìGabriella Fontanini
Mar 1, 2008·Expert Review of Endocrinology & Metabolism·Kathrin ZitzmannChristoph J Auernhammer
Jan 21, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Joseph D ValentinoB Mark Evers
Oct 16, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jessica E MaxwellJames R Howe
Aug 19, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ignacio DuranLillian L Siu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.