Epidermal growth factor receptor expression by acoustic neuromas

The Laryngoscope
E M SturgisR G Amedee

Abstract

Antibodies directed against epidermal growth factor receptor (EGFr) impede proliferation and induce differentiation of EGFr-positive cancers. To explore the effectiveness of anti-EGFr monoclonal antibodies on acoustic neuromas (ANs), we first sought to evaluate EGFr expression by ANs. The records of all patients with the diagnosis of AN at our institution from January 1989 to July 1994 were reviewed. Immunohistochemical analysis for EGFr was performed on formalin-fixed, paraffin-embedded archival surgical specimens. Skin, liver, and placenta were used as positive tissue controls. Purified rabbit immunoglobulin G replacing the experimental antibody acted as a negative control, and normal eighth cranial nerve was evaluated for background staining. Slides were scored as 0, +, ++, or and for percentage of positive cells by two pathologists, with Antoni A and Antoni B areas scored separately. Results demonstrate that most tumors are revealed to be EGFr positive with a mild degree of staining. Antoni A areas generally have greater staining than Antoni B regions, while normal eighth cranial nerves demonstrate minimal background staining. These results suggest that ANs express low levels of EGFr, with Antoni A areas having the highest ...Continue Reading

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Citations

Nov 26, 2010·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Carrie M BrownJoni K Doherty
Dec 12, 2012·Virchows Archiv : an International Journal of Pathology·Maurits de VriesPancras C W Hogendoorn
Jan 18, 2008·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Joni K DohertyAllen F Ryan
Aug 26, 2010·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Scott R PlotkinFred G Barker
Dec 16, 2010·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Xabier AltunaWeg M Ongkeko
Dec 24, 2010·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Katherine J BlairWeg M Ongkeko
Oct 30, 2007·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Agadha WickremesekeraAndrew H Kaye
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Oct 18, 2011·Acta otorrinolaringológica española·Xabier AltunaWeg Ongkeko

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