Epidermal growth factor receptor induced Erk phosphorylation in the suprachiasmatic nucleus

Brain Research
Haiping Hao, James S Schwaber

Abstract

A significant functional role for epidermal growth factor receptor (EGFR) in the suprachiasmatic nucleus (SCN) is suggested by the confluence of several recent findings: (1) EGFR is highly expressed in the SCN, (2) the EGFR ligand TGFalpha is expressed and apparently locally released in the SCN, and (3) EGFR activation local to the 3rd ventricle suppresses circadian locomotor behavior and drinking/feeding activities. However, it has not yet been shown that binding of EGFR in the SCN can activate the key signaling pathways associated with its function. Here, we report that EGF treatment induced Erk1/2 phosphorylation in the rat SCN cells. The observation indicates functional EGFR in the SCN and motivates further investigation of the functional role of these receptors.

References

Jul 12, 2002·Cell and Tissue Research·Martha U Gillette, Jennifer W Mitchell
Aug 29, 2002·Nature·Steven M Reppert, David R Weaver
Feb 10, 2004·Frontiers in Bioscience : a Journal and Virtual Library·Cory J Xian, Xin-Fu Zhou
Apr 28, 2004·Cytokine & Growth Factor Reviews·Richard Wing Chuen Wong, Laurent Guillaud
Feb 11, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jorge MendozaEtienne Challet

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Citations

Dec 7, 2007·Journal of Molecular Neuroscience : MN·Gastón A Pizzio, Diego A Golombek
Dec 27, 2008·Behavioural Brain Research·Jenifer Gilbert, Fred C Davis
Apr 21, 2007·The European Journal of Neuroscience·Yukako WakatsukiShigenobu Shibata
May 7, 2019·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Dilshan H BeligalaMichael E Geusz

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