Epidermal Growth Factor Receptor Inhibition in the Management of Squamous Cell Carcinoma of the Lung

The Oncologist
Glenwood D Goss, Johanna N Spaans

Abstract

Molecular therapies targeting epidermal growth factor receptor (EGFR) have had a profound impact on the management of advanced non-small cell lung cancer (NSCLC). EGFR inhibition with EGFR tyrosine kinase inhibitors (EGFR-TKIs) and anti-EGFR monoclonal antibodies (mAbs) in squamous NSCLC (sqNSCLC) remains controversial in patients whose tumors are not known to harbor EGFR mutations. Recent meta-analyses of EGFR-inhibition randomized trials that are adequately powered for histological subgroup analysis and anti-EGFR trials limited to patients with squamous histology afford the opportunity to revisit EGFR treatment in sqNSCLC. In unselected patients with sqNSCLC who are not eligible for chemotherapy, EGFR-TKI therapy is a valid treatment option over placebo or best supportive care, with improved progression-free survival noted in randomized controlled trials in both the first- and second-line setting and improved overall survival (OS) in the second-line setting. In patients eligible for chemotherapy, first-line combination regimens with anti-EGFR mAbs have been shown to improve OS over chemotherapy alone in patients with squamous histology in meta-analysis and more recently in the SQUIRE sqNSCLC trial (chemotherapy with and witho...Continue Reading

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Citations

Feb 28, 2018·Journal of Ovarian Research·Ke ZhangBaoyun Zhang
Jun 20, 2018·Journal of Clinical Medicine·Tamkin AhmadzadaWendy A Cooper
Nov 6, 2018·Expert Opinion on Pharmacotherapy·Marco TagliamentoFrancesco Grossi

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