Epidermal growth factor receptor targeted therapy with gefitinib in locally advanced and metastatic primary lung adenocarcinoma

Respirology : Official Journal of the Asian Pacific Society of Respirology
Chong-Kin LiamChai-Hooi Leow

Abstract

To describe the efficacy of monotherapy with the epidermal growth factor receptor-tyrosine kinase inhibitor, gefitinib in patients with locally advanced and metastatic primary lung adenocarcinoma. A retrospective analysis was undertaken of patients who had locally advanced or metastatic lung adenocarcinoma treated with gefitinib 250 mg orally once daily until disease progression. All patients had either been previously treated with systemic cytotoxic chemotherapy and/or radiotherapy or had declined chemotherapy or were medically not fit for cytotoxic chemotherapy. A total of 23 patients (13 men) (15 never smokers) with a median age of 51 years (range 35-79 years) received gefitinib monotherapy. Disease control occurred in 14 patients (61%); there was a reduction in the size of the primary and/or metastatic tumours (partial response (PR)) in 11 patients (48%), and 3 patients (13%) had stable disease. The response rate was significantly higher in those who had never smoked (10 of 15 (67%)) compared with that of smokers (1 of 8 (13%)) (odds ratio (95% confidence interval), 14.0 (1.33-147.43) P=0.027). In total, 11 of 18 patients (61%) with a WHO performance status 1 or 2 showed a PR, whereas none with a performance status 3 or 4 r...Continue Reading

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Citations

Oct 21, 2006·Respirology : Official Journal of the Asian Pacific Society of Respirology·Katsunori KagohashiMorio Ohtsuka
Jan 9, 2007·Respirology : Official Journal of the Asian Pacific Society of Respirology·Y C Gary Lee, Richard Beasley
Jul 17, 2012·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Fausto PetrelliSandro Barni

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