PMID: 6966378May 22, 1980Paper

Epidermal growth factor requirement for development of cultured mammary gland

Nature
Q J Tonelli, S Sorof

Abstract

The mouse mammary gland in serum-free whole organ culture can be manipulated hormonally to undergo one complete physiological cycle consisting of lobuloalveolar development, functional differentiation and regression, mimicking processes that occur in vivo. A second cycle has not previously been achieved in vitro. The present study has identified a specific requirement for epidermal growth factor (EGF) in the morphological development of mammary lobuloalveoli, allowing two complete cycles of development and regression in culture.

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Citations

May 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S L FerrariJ P Bonjour
Jan 1, 1988·Virchows Archiv. A, Pathological Anatomy and Histopathology·S Battersby, T J Anderson
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