Epidermal keratin levels during oral 1-alpha-hydroxyvitamin D3 treatment for psoriasis.

Skin Pharmacology : the Official Journal of the Skin Pharmacology Society
D B HollandW J Cunliffe

Abstract

Recently the treatment of psoriasis with vitamin D3, its metabolites or analogues, has been reported to be clinically effective and free from side effects. We have quantified the changes in the levels of epidermal lesional keratins in 15 psoriatic patients receiving oral 1 alpha(OH)D3 treatment. Lesions were sampled before treatment commenced and at monthly intervals for 4-6 months. Clinical resolution occurred in 7 patients within this time; 3 other patients showed incomplete lesion resolution and the remaining 5 patients showed a complete lack of response within the treatment period. Lesion resolution, as judged by clinical criteria, was accompanied by significant changes in the levels of three of the keratin polypeptides and smaller changes in others. Keratin 2 increased to levels greater than those in normal epidermis, while keratins 16 and 18 decreased to normal levels. Changes in the levels of keratins 1 and 5 were small and those of keratins 7, 10 and 14 minimal. These changes were compared with values found during lesion resolution with other therapies used in psoriasis, i.e. topical dithranol, PUVA, oral etretinate and hydroxyurea and were highly reminiscent of those observed during PUVA therapy but contrasted with tho...Continue Reading

Citations

Oct 20, 2004·Journal of Cutaneous Pathology·Chad HivnorJohn Seykora
Jan 1, 1992·Archives of Dermatological Research·K Kragballe
Aug 1, 1992·The British Journal of Dermatology·J Berth-Jones, P E Hutchinson
Jul 5, 2017·Archives of Dermatological Research·R Hambly, B Kirby
May 1, 1992·Journal of Cellular Biochemistry·K Kragballe
Aug 1, 1992·Journal of Clinical Pharmacy and Therapeutics·J Berth-Jones, P E Hutchinson
Jan 10, 2021·Nutrients·Ana Maria Alexandra StanescuCamelia Cristina Diaconu
Jun 12, 1999·Journal of the American Academy of Dermatology·F A CastelijnsP C van de Kerkhof

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