PMID: 9182813Jun 1, 1997Paper

Epidermal steroid sulfatase and cholesterol sulfotransferase are regulated during late gestation in the fetal rat

The Journal of Investigative Dermatology
K HanleyMary L Williams

Abstract

Lipids in the stratum corneum (SC) are organized into lamellar membrane unit structures that provide the permeability barrier. Cholesterol sulfate, a SC membrane lipid, is synthesized by cholesterol sulfotransferase (CSTase) in the lower epidermis and hydrolyzed to cholesterol by steroid sulfatase (SSase) in the SC. To determine whether these enzymes are induced during barrier ontogenesis, we examined their activity in epidermis of fetal rats before (gestational day 17), during (day 19), and after (day 21) barrier formation. CSTase activity increased approximately 10-fold between day 17 and day 19, then declined between day 19 and day 21. In contrast, SSase activity reached its peak activity on day 21, increasing >5-fold. Fetal rat skin explants develop a SC and barrier over the same time course in vitro as in utero. Likewise, CSTase and SSase activities during in vitro ontogenesis precisely mirrored those obtained in utero. Moreover, hormones that accelerate barrier ontogenesis (e.g. glucocorticoids, thyroid hormone, and estrogen) accelerated the increase in CSTase and SSase activities during in vitro ontogenesis. mRNA levels of SSase increased in parallel with enzymatic activity, suggesting that these developmental changes ar...Continue Reading

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Citations

May 6, 2003·Journal of Lipid Research·Charles A Strott, Yuko Higashi
Jul 11, 2006·Journal of Lipid Research·Yan J JiangKenneth R Feingold
Aug 12, 2008·Thyroid : Official Journal of the American Thyroid Association·Monica Dentice, Giuseppe Monfrecola
Aug 24, 2012·Current Opinion in Endocrinology, Diabetes, and Obesity·Joshua D Safer
Sep 10, 2005·Journal of Lipid Research·Yan J JiangKenneth R Feingold
Apr 9, 1999·The Journal of Clinical Investigation·V A GaltonD L St Germain
Sep 10, 2005·Journal of Lipid Research·Biao LuKenneth R Feingold
Apr 12, 2013·Journal of Thyroid Research·Joshua D Safer
Jan 20, 2017·Advanced Pharmaceutical Bulletin·Mitra NiafarNader D Nader
Apr 16, 1998·The Journal of Investigative Dermatology·P M EliasK R Feingold
Nov 6, 1998·The Journal of Investigative Dermatology·E ZetterstenP M Elias
Sep 18, 1998·The Journal of Investigative Dermatology·K HanleyM L Williams
Dec 18, 2002·The Journal of Investigative Dermatology·Matthias SchmuthKenneth R Feingold

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