Epidermolysis Bullosa Acquisita: From Pathophysiology to Novel Therapeutic Options

The Journal of Investigative Dermatology
M KasperkiewiczRalf J Ludwig

Abstract

Epidermolysis bullosa acquisita (EBA) is a prototypic organ-specific autoimmune disease induced by autoantibodies to type VII collagen causing mucocutaneous blisters. In the inflammatory (bullous pemphigoid-like) EBA variant, autoantibody binding is followed by a lesional inflammatory cell infiltration, and the overall clinical picture may be indistinguishable from that of bullous pemphigoid, the latter being the most common autoimmune bullous disease. The last decade witnessed the development of several mouse models of inflammatory EBA that facilitated the elucidation of the pathogenesis of autoantibody-induced, cell-mediated subepidermal blistering diseases and identified new therapeutic targets for these and possibly other autoantibody-driven disorders.

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Citations

Dec 25, 2016·The Journal of Investigative Dermatology·Robert Pollmann, Rüdiger Eming
Feb 6, 2017·Experimental Dermatology·Johanna M BrandnerRalf J Ludwig
Jan 22, 2017·Seminars in Diagnostic Pathology·Mark R Wick
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Dec 12, 2017·Frontiers in Immunology·Katja BieberRalf J Ludwig
Feb 21, 2019·Current Protocols in Pharmacology·Anika KasprickRalf J Ludwig
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Jun 18, 2017·Frontiers in Immunology·Ralf J LudwigFalk Nimmerjahn
Nov 7, 2017·Experimental Dermatology·Delphine GiustiFrank Antonicelli
Dec 7, 2018·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·Franziska HübnerEnno Schmidt
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Jan 23, 2021·Journal of Clinical Medicine·Elisabetta AntonelliGiovanni Maconi
Aug 10, 2020·Journal of Autoimmunity·Tanya SezinChristian D Sadik
Feb 21, 2021·The Journal of Investigative Dermatology·Paul SchilfChristian D Sadik
Mar 9, 2021·Journal of the American Academy of Dermatology·Carmen M MontagnonJulia S Lehman
May 26, 2021·The Journal of Investigative Dermatology·Sripriya MurthyChristian D Sadik

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