Epidermolysis bullosa acquisita responsive to dapsone therapy

Journal of Cutaneous Medicine and Surgery
A P Hughes, J P Callen

Abstract

Epidermolysis bullosa acquisita (EBA) is a chronic subepidermal blistering disease that is frequently resistant to therapy. A 58-year-old man who had a one-year history of a bullous eruption involving the hands, forearms, trunk, scalp, and oral mucosa. Histopathology revealed a subepidermal bulla, and direct and indirect immunofluorescence studies were consistent with EBA. The patient failed respond to niacinamide and tetracycline and oral prednisone 40 mg per day. Complete control of his blistering was achieved within two months of initiating oral dapsone, 150 mg per day. Dapsone may be an effective agent for some patients with EBA.

Citations

Sep 8, 2004·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·S RitzmannM Megahed
Mar 25, 2008·Therapeutics and Clinical Risk Management·Diya F Mutasim
May 9, 2012·Immunology and Allergy Clinics of North America·Evan W Piette, Victoria P Werth
Sep 20, 2011·Dermatologic Clinics·Evan W Piette, Victoria P Werth
Feb 20, 2008·Immunology and Allergy Clinics of North America·Samih ElchahalDavid S Chu
Mar 6, 2009·International Journal of Dermatology·Julia S LehmanLawrence E Gibson
Feb 5, 2009·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Marco Carrozzo
Sep 6, 2007·The Journal of Small Animal Practice·P B HillT Olivry
Nov 3, 2009·Journal of Cellular and Molecular Medicine·Gheorghe HundorfeanCassian Sitaru
Dec 8, 2004·Journal of the American Academy of Dermatology·Diya F Mutasim
Jan 25, 2011·Expert Opinion on Pharmacotherapy·Hakan M Gürcan, A Razzaque Ahmed
Jan 20, 2007·Journal of Cutaneous Medicine and Surgery·P Régine MydlarskiNeil H Shear
Feb 18, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·M GibsonD F Murrell

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.