PMID: 9185908Jun 1, 1997Paper

Epidermolytic acanthomas: clinical characteristics and immunohistochemical features

The American Journal of Dermatopathology
P R CohenM Duvic

Abstract

Epidermolytic hyperkeratosis in bullous congenital ichthyosiform erythroderma results from mutations in the K1 and K10 genes. Epidermolytic acanthomas are solitary or multiple lesions with microscopic features that are identical to those in bullous congenital ichthyosiform erythroderma. In this study, the clinical and epidemiologic characteristics of epidermolytic acanthomas were summarized, and the expression of keratins (using antibodies to K1, K6, K10, K14, K16, and K19) in five solitary epidermolytic acanthomas was determined using immunohistochemistry techniques. The intensity of staining for K1 and K10 was (a) less in the altered granular layer, as compared to the adjacent nonaltered granular layer of the lesional skin, and (b) less in the lesional skin as compared to the perilesional, histologically normal-appearing skin. Expression of K6 and K16 was noted not only in the basal layer and suprabasal layers of the lesions, but also in the corresponding layers of the adjacent normal skin. Staining for K14 was also observed in the basal layers and suprabasal layers of the lesional and adjacent normal epidermis; within the lesional and perilesional normal skin, the intensity of positive staining for K14 was greater in the bas...Continue Reading

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Citations

Sep 24, 2005·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Marcia L UsuiJohn E Olerud
Mar 8, 2016·The Journal of Dermatology·Takeya AdachiAkira Ishiko
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Sep 7, 2004·Clinical and Experimental Dermatology·J P BankyK Hollowood
Mar 14, 2007·The Journal of Dermatology·Bong-Seok JangKyung-Sool Kwon
Jun 20, 2013·Clinical and Experimental Dermatology·D VelázquezJ M Hernanz
May 29, 2013·Journal of Cutaneous Pathology·Viktoryia KazlouskayaDirk Elston
Jun 18, 2010·Journal of the European Academy of Dermatology and Venereology : JEADV·O AbbasL J Goldberg
Apr 8, 2014·Dermatologic Therapy·Grace Feng-Ling TanHong Liang Tey
Oct 30, 2016·Annales de dermatologie et de vénéréologie·I MoulonguetD Herskovitch
Sep 13, 2011·Annals of Dermatology·Ji-Hye YangKee-Chan Moon
Jan 22, 2019·Journal of Cutaneous Pathology·Simon F RoyJennifer M McNiff
Oct 26, 2018·Clinical and Experimental Dermatology·W T Lam, K W Tan
Sep 12, 2018·Archives of Pathology & Laboratory Medicine·May P Chan
Nov 28, 2018·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Steven IrwinW Glenn McCluggage
Feb 12, 2020·Journal of Cutaneous Pathology·Shayan CheraghlouKeith A Choate
Jul 23, 2014·The American Journal of Dermatopathology·Maya M HijaziSamer Ghosn
Sep 5, 2017·Case Reports in Dermatology·Salinee RojhirunsakoolKumutnart Chanprapaph
Oct 8, 2020·World Journal of Clinical Cases·Ariana S GinsbergJoseph P Terlizzi
Apr 30, 2021·Annals of Dermatology·Hyun Jeong ByunDong-Youn Lee

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