PMID: 8985776Oct 1, 1996Paper

Epididymal oxytocin in the rat: its origin and regulation

International Journal of Andrology
G C HarrisH D Nicholson

Abstract

Oxytocin is localized to the Leydig cells of the testis in the rat and several other species where it is postulated to play a role in steroidogenesis and seminiferous tubule contractility. Oxytocin has also been detected in the epididymis of the ram where active uptake of the peptide from luminal fluid has been demonstrated. This study was performed to investigate whether oxytocin is present in the rat epididymis, and the origin of the peptide. Immunoactive oxytocin was detected in the epididymis of all control animals examined (147.7 +/- 41.7 pg/g). Total epididymal oxytocin was reduced significantly following castration (p < 0.05). Testosterone treatment also reduced the epididymal concentration of the peptide in both intact and castrated rats. Efferent duct ligation (EDL) did not affect the presence of oxytocin in the epididymis. Immunoactive oxytocin was localized in discrete cells of the epithelium of the caput epididymis, with less staining apparent in the initial segment and cauda epididymis. Staining disappeared from the caput epididymis following castration, but reappeared following testosterone supplementation. No obvious alteration in staining was observed in the cauda epididymis after EDL. These data demonstrate for...Continue Reading

References

Aug 1, 1991·The Journal of Endocrinology·H D NicholsonB T Pickering
Sep 1, 1988·Biology of Reproduction·J J KnickerbockerG D Niswender
Mar 1, 1984·Regulatory Peptides·H D NicholsonB T Pickering
Sep 1, 1981·Journal of Reproduction and Fertility·U M Jaakkola, A Talo
Jul 1, 1996·Journal of Reproduction and Fertility·J FrayneH D Nicholson

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Citations

Mar 23, 2000·Theriogenology·E D WatsonJ Goode
Aug 22, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·Marco MeweChristiane K Bauer
Aug 21, 2012·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Hirofumi HashimotoYoichi Ueta
Aug 8, 2014·Frontiers in Neuroscience·Hirofumi HashimotoYoichi Ueta
Jan 27, 2006·Human Reproduction Update·Hemlata ThackareKate Whittington
Jun 27, 1998·Archives of Andrology·H J GoverdeE J Meuleman
Dec 1, 2010·Biomolecular Concepts·Nicole C Tom, Stephen J Assinder
Jul 30, 2020·American Journal of Physiology. Cell Physiology·Dong-Dong GaoWen-Liang Zhou
Mar 29, 2001·Physiological Reviews·G Gimpl, F Fahrenholz
Aug 23, 2000·Biology of Reproduction·B L CheukP Y Wong
Nov 17, 2020·Frontiers in Endocrinology·Beatrix StadlerRalf Middendorff

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