Epidural anaesthesia restores pancreatic microcirculation and decreases the severity of acute pancreatitis

World Journal of Gastroenterology : WJG
Alp DemiragLeo H Bühler

Abstract

To investigate the effect of epidural anaesthesia (EA) on pancreatic microcirculation during acute pancreatitis (AP). AP was induced by injection of sodium taurocholate into the pancreatic duct of Sprague-Dawley rats. To realize EA, a catheter was introduced into the epidural space between T7 and T9 and bupivacaine was injected. Microcirculatory flow was measured by laser Doppler flowmetry. Arterial blood gas analyses were performed. At the end of the experiment (<or=5 h), pancreas was removed for histology. The animals were divided into three groups: Group 1 (n=9), AP without EA; Group 2 (n=4), EA without AP; and Group 3 (n=6), AP treated by EA. In Group 1, pancreatic microcirculatory flow prior to AP was 141+/- 39 perfusion units (PU). After AP, microcirculatory flow obviously decreased to 9+/- 6 PU (P<0.05). Metabolic acidosis developed with base excess (BE) of -14+/-3 mmol/L. Histology revealed extensive edema and tissue necrosis. In Group 2, EA did not significantly modify microcirculatory flow. BE remained unchanged and histological analysis showed normal pancreatic tissue. In Group 3, AP initially caused a significant decrease in microcirculatory flow from 155+/-25 to 11+/-7 PU (P<0.05). After initiation of EA, microcirc...Continue Reading

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Citations

Aug 8, 2006·Current Opinion in Gastroenterology·Stephen J Pandol
Oct 21, 2014·Mediators of Inflammation·Lars HållströmAnne Soop
Nov 26, 2015·World Journal of Gastroenterology : WJG·Samira M SadowskiLeo Bühler
Oct 19, 2012·Medizinische Klinik, Intensivmedizin und Notfallmedizin·G Weitz
Jul 7, 2017·Scandinavian Journal of Gastroenterology·Kirsten Lykke WahlstrømMark Berner Hansen
Dec 2, 2017·Critical Care Medicine·Matthieu JabaudonUNKNOWN Azurea Network
Jan 5, 2020·Journal of Thrombosis and Thrombolysis·Michael A VellaAdam Shiroff
May 5, 2016·Critical Care : the Official Journal of the Critical Care Forum·Olivier WindischLéo Bühler
Nov 4, 2017·Southern Medical Journal·Shirin MajidiErrington C Thompson
Aug 3, 2012·Regional Anesthesia and Pain Medicine·Ottokar Stundner, Stavros G Memtsoudis
May 16, 2019·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Asha TyagiArun Gupta
Aug 23, 2008·Bioconjugate Chemistry·Diego A GianolioRobert J Miller
May 16, 2019·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Deepak Govil, Mozammil Shafi

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