Epidural analgesia and mortality after colorectal cancer surgery: A retrospective cohort study.

Annals of Medicine and Surgery
Wiebke FalkShahin Mohseni

Abstract

Epidural analgesia (EA) has been the standard of care after major abdominal surgery for many years. This study aimed to correlate EA with postoperative complications, short- and long-term mortality in patients with and without EA after open surgery (OS) and minimally invasive surgery (MIS) for colorectal cancer. Patient, clinical and outcome data were obtained from the Swedish Colorectal Cancer Registry and the Swedish Perioperative Registry. All adult patients diagnosed with colorectal cancer without metastases who underwent elective curative MIS or OS for colorectal cancer between January 2016 and December 2018 and who had data recorded in both registries, were included in the study. Data were analyzed for OS and MIS procedures separately. A Poisson regression model was used to investigate the association between EA and the outcomes of interest. Five thousand seven hundred sixty-two patients were included in the study, 2712 in the MIS and 3050 patients in the OS group. After adjusting for patient specific and clinically relevant variables in the regression model, no statistically significant difference in risk for complications; 30-day, 90-day, and up to 3-year mortality following either MIS or OS could be detected between th...Continue Reading

References

Aug 23, 2003·Anesthesia and Analgesia·Benzion BeilinHanna Bessler
May 12, 2004·Surgical Endoscopy·M BuunenN D Bouvy
Sep 10, 2004·American Journal of Therapeutics·Ricardo VallejoRamsun Benyamin
May 22, 2007·The British Journal of Surgery·E MarretUNKNOWN Postoperative Pain Forum Group
Jul 19, 2008·Anesthesia and Analgesia·Rose ChristophersonFrank E Johnson
Mar 31, 2011·BMJ : British Medical Journal·Paul S MylesUNKNOWN ANZCA Trials Group Investigators
Jun 28, 2012·British Journal of Anaesthesia·J HermanidesP Lirk
Aug 20, 2014·Anesthesia and Analgesia·Fabian O KooijMarkus W Hollmann
Feb 18, 2015·Gastroenterology Report·F Jeroen VogelaarKoop Bosscha
Oct 29, 2015·European Journal of Anaesthesiology·Narinder Rawal
Jan 19, 2018·Surgical Endoscopy·Michael P M de Neree Tot BabberichUNKNOWN Dutch Surgical Colorectal Audit
Nov 11, 2019·International Journal of Surgery·Riaz AghaUNKNOWN STROCSS Group

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R Foundation for Statistical Computing
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