PMID: 11915058Mar 27, 2002Paper

Epidural analgesia and postoperative lipid metabolism: stable isotope studies during a fasted/fed state

Regional Anesthesia and Pain Medicine
F CarliT Schricker

Abstract

Although previous studies have reported an inhibitory effect of epidural block and glucose feeding on plasma concentrations of glycerol and free fatty acids (FFA), it remains unclear how epidural analgesia modifies the postoperative production and uptake of lipid metabolites. This can be achieved by determining the rate of lipolysis during a feeding state with dextrose. Twelve patients with or without postoperative epidural analgesia were studied 48 hours after surgery. They underwent a 6-hour stable isotope infusion study using [1,1,2,3,3,-(2)H(5)] glycerol; 3 hours of fasting, and 3 hours of dextrose infusion (4 mg/kg/min). The rate of glycerol appearance (R(a) glycerol) i.e., rate of lipolysis, and plasma concentrations of glycerol, FFA, glucose, lactate, insulin, glucagon, and cortisol were measured during the fasted and the fed states. The rates of lipolysis were similar in both groups during the fasted state and were not modified by dextrose infusion. In contrast, plasma concentrations of glycerol and FFA were decreased significantly during the fed state (P <.01). Glycerol clearance (ratio between R(a) glycerol and plasma glycerol concentration) increased significantly in both groups (P <.05) with feeding. Similarly, plas...Continue Reading

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Citations

Aug 12, 2009·Der Anaesthesist·S Reichl, E Pogatzki-Zahn
Mar 5, 2019·International Journal of Prisoner Health·Emanuela SaitaDel Loewenthal
May 18, 2007·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·K A GendallF A Frizelle

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